Mouse CXCL2/MIP-2 Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse CXCL2/MIP-2 Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse MIP-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse MIP-2 levels in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse MIP-2 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse MIP-2 accurately. Results obtained using natural mouse MIP-2 ...showed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse MIP-2.
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• Specificity: Natural and recombinant mouse MIP-2
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CXCL2/MIP-2 Quantikine ELISA Kit, 2 Plate

• chemokine (C-X-C motif) ligand 2
• CINC-2a
• CINC3
• CINC-3
• C-X-C Motif Chemokine 2
• CXCL2
• GRO beta
• GRO2 oncogene
• GRO2
• GROB
• Gro-beta
• Growth-regulated protein beta
• Macrophage inflammatory protein 2-alpha
• melanoma growth stimulatory activity beta
• MGSA beta
• MGSA-b
• MGSA-beta
• MIP2
• MIP-2
• MIP2A
• MIP-2a
• MIP2-alpha
• SCYB2

Background

CXCL2/GRO beta, also called MIP-2 in mouse and CINC-3 in rat, is a member of the CXC chemokine family. Human CXCL2/GRO beta is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 70% and 71% aa sequence identity with the human protein, respectively. N-terminal aa 1-4 of CXCL2/GRO beta can be post-translationally cleaved which confers enhanced hematopoietic bioactivity. CXCL2/GRO beta is produced by a variety of cell types including monocytes and macrophages at sites of inflammation and is chemotactic for granulocytes, including neutrophils.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CXCL2/GRO beta/MIP-2/CINC-3 (MM200)(169)

Publications using MM200

• Lei, Z;Krishnamachary, B;Ritzel, RM;Khan, NZ;Li, Y;Li, H;Brunner, K;Faden, AI;Wu, J; Age-related changes in plasma extracellular vesicles influence neuroinflammation in the brain and neurological outcome after traumatic spinal cord injury Research square 2023-04-17 [PMID: 37131758] (Mouse)
• S Luo, C Liao, L Zhang, C Ling, X Zhang, P Xie, G Su, Z Chen, L Zhang, T Lai, J Tang METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling Cell Reports, 2023-03-14;42(3):112259. 2023-03-14 [PMID: 36920907] (Mouse)
• DW Chen, T Kang, XZ Xu, WJ Xia, X Ye, YB Wu, YR Xu, J Liu, H Ren, J Deng, YK Chen, HQ Ding, M Aslam, WM Zelek, BP Morgan, R Kapur, S Santoso, YS Fu Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies JCI Insight, 2023-03-22;0(0):. 2023-03-22 [PMID: 36809299] (Mouse)
• K Thomas, L Zondler, N Ludwig, M Kardell, C Lüneburg, K Henke, S Mersmann, A Margraf, T Spieker, T Tekath, A Velic, R Holtmeier, J Hermann, V Jankowski, M Meersch, D Vestweber, M Westphal, J Roth, MA Schäfers, JA Kellum, CA Lowell, J Rossaint, A Zarbock Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells JCI Insight, 2022-11-08;7(21):. 2022-11-08 [PMID: 36107633] (Mouse)
• Y Ni, GH Wu, JJ Cai, R Zhang, Y Zheng, JQ Liu, XH Yang, X Yang, Y Shen, JM Lai, XM Ye, SJ Mo Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation International journal of biological sciences, 2022-08-08;18(13):5168-5184. 2022-08-08 [PMID: 35982894] (Mouse)
• WJ Kelley, KM Wragg, J Chen, T Murthy, Q Xu, MT Boyne Ii, JR Podojil, A Elhofy, DR Goldstein Nanoparticles reduce monocytes within the lungs to improve outcomes after influenza virus infection in aged mice JCI Insight, 2022-08-08;0(0):. 2022-08-08 [PMID: 35737459] (Mouse)
• Y Uchida, Y Nariai, E Obayashi, Y Tajima, T Koga, A Kawakami, T Urano, H Kamino Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases Oncogene, 2022-06-13;727(0):109322. 2022-06-13 [PMID: 35709966] (Mouse)
• X Han, J Ren, H Lohner, L Yakoumatos, R Liang, H Wang SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity The Journal of Biological Chemistry, 2022-05-17;0(0):102036. 2022-05-17 [PMID: 35588785] (Mouse)
• P Wolinski, D Ksiazek-Wi, A Glabinski Cytokines and Neurodegeneration in Epileptogenesis Brain sciences, 2022-03-12;12(3):. 2022-03-12 [PMID: 35326336] (Mouse)
• T Nagatake, S Kishino, E Urano, H Murakami, N Kitamura, K Konishi, H Ohno, P Tiwari, S Morimoto, E Node, J Adachi, Y Abe, J Isoyama, K Sawane, T Honda, A Inoue, A Uwamizu, T Matsuzaka, Y Miyamoto, SI Hirata, A Saika, Y Shibata, K Hosomi, A Matsunaga, H Shimano, M Arita, J Aoki, M Oka, A Matsutani, T Tomonaga, K Kabashima, M Miyachi, Y Yasutomi, J Ogawa, J Kunisawa Intestinal microbe-dependent ?3 lipid metabolite alphaKetoA prevents inflammatory diseases in mice and cynomolgus macaques Mucosal Immunology, 2022-01-10;0(0):. 2022-01-10 [PMID: 35013573] (Mouse)
• Y Zhou, J Hann, V Schenten, S Plançon, JL Bueb, F Tolle, S Bréchard Role of S100A8/A9 for Cytokine Secretion, Revealed in Neutrophils Derived from ER-Hoxb8 Progenitors International Journal of Molecular Sciences, 2021-08-17;22(16):. 2021-08-17 [PMID: 34445548] (Mouse)
• T Lin, D Quellier, J Lamb, T Voisin, P Baral, F Bock, A Schönberg, R Mirchev, G Pier, I Chiu, M Gadjeva Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection PloS Pathogens, 2021-05-06;17(5):e1009557. 2021-05-06 [PMID: 33956874] (Mouse)
• SN Chang, DK Dey, ST Oh, WH Kong, KH Cho, EM Al-Olayan, BS Hwang, SC Kang, JG Park Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1&alpha-NF-&kappaB Crosstalk In Vitro and In Vivo International Journal of Molecular Sciences, 2020-12-04;21(23):. 2020-12-04 [PMID: 33291656] (Mouse)
• MT Hoffman, SB Kemp, DJ Salas-Esca, Y Zhang, NG Steele, S The, D Long, S Benitz, W Yan, RF Margolskee, F Bednar, M Pasca di M, HJ Wen, HC Crawford The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice Cell Mol Gastroenterol Hepatol, 2020-08-31;0(0):. 2020-08-31 [PMID: 32882403] (Mouse)
• WC Chen, NJ Chen, HP Chen, WK Yu, VY Su, H Chen, HH Wu, KY Yang Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis Int J Mol Sci, 2020-07-02;21(13):. 2020-07-02 [PMID: 32630825] (Mouse)
• M Yoshikawa, T Iriyama, K Suzuki, S Sayama, T Tsuruga, K Kumasawa, T Nagamatsu, K Homma, I Naguro, Y Osuga, H Ichijo, T Fujii ASK1 promotes uterine inflammation leading to pathological preterm birth Sci Rep, 2020-02-05;10(1):1887. 2020-02-05 [PMID: 32024889] (Mouse)
• JJ Yang, YC Huang, TH Chuang, DR Herr, MF Hsieh, CJ Huang, CM Huang Cysteine-Capped Hydrogels Incorporating Copper as Effective Antimicrobial Materials against Methicillin-Resistant Staphylococcus aureus Microorganisms, 2020-01-21;8(2):. 2020-01-21 [PMID: 31973160] (Mouse)
• M Matsuda, K Doi, T Tsutsumi, M Inaba, J Hamaguchi, T Terada, R Kawata, K Kitatani, T Nabe Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice J. Pharmacol. Sci., 2019-11-02;141(4):139-145. 2019-11-02 [PMID: 31744690] (Mouse)
• K Nakajima, M Ono, U Radovi?, S Dizdarevi?, SI Tomizawa, K Kuroha, G Naganatsu, I Hoshi, R Matsunaga, T Shirakawa, T Kurosawa, Y Miyazaki, M Seki, Y Suzuki, H Koseki, M Nakamura, T Suda, K Ohbo Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice Dis Model Mech, 2019-11-12;0(0):. 2019-11-12 [PMID: 31562139] (Mouse)
• K Kojima, K Asai, H Kubo, A Sugitani, Y Kyomoto, A Okamoto, K Yamada, N Ijiri, T Watanabe, K Hirata, T Kawaguchi Isoflavone Aglycones Attenuate Cigarette Smoke-Induced Emphysema via Suppression of Neutrophilic Inflammation in a COPD Murine Model Nutrients, 2019-08-29;11(9):. 2019-08-29 [PMID: 31470503] (Mouse)
• YF Wu, ZY Li, LL Dong, WJ Li, YP Wu, J Wang, HP Chen, HW Liu, M Li, CL Jin, HQ Huang, SM Ying, W Li, HH Shen, ZH Chen Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation Autophagy, 2019-06-16;0(0):1-16. 2019-06-16 [PMID: 31203721] (Mouse)
• KJ Warren, JD Dickinson, AJ Nelson, TA Wyatt, DJ Romberger, JA Poole Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust Respir. Res., 2019-03-07;20(1):51. 2019-03-07 [PMID: 30845921] (Mouse)
• N Simon, A Antignani, SM Hewitt, M Gadina, C Alewine, D FitzGerald Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells JCI Insight, 2019-03-07;0(0):. 2019-03-07 [PMID: 30720466] (Mouse)
• VY Su, KY Yang, SH Chiou, NJ Chen, MH Mo, CS Lin, CT Wang Induced Pluripotent Stem Cells Regulate TREM-1 Expression and the p38 MAPK Pathway in Endotoxin-Induced Acute Lung Injury Stem Cells, 2019-02-16;0(0):. 2019-02-16 [PMID: 30681755] (Mouse)
• J Jeong, YJ Kim, DY Lee, BG Moon, KY Sohn, SY Yoon, JW Kim 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) attenuates gemcitabine-induced neutrophil extravasation Cell Biosci, 2019-01-03;9(0):4. 2019-01-03 [PMID: 30622698] (Mouse)
• J Lou, Y Hu, MD Wu, LQ Che, YF Wu, Y Zhao, BP Tian, ZQ Bao, C Zhu, YP Wu, LL He, CX Bai, J Zhou, SM Ying, W Li, ZH Chen, DX Chen, A Dorling, HH Shen Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury Acta Pharmacol. Sin., 2018-11-16;0(0):. 2018-11-16 [PMID: 30446733] (Mouse)
• M Taki, K Abiko, T Baba, J Hamanishi, K Yamaguchi, R Murakami, K Yamanoi, N Horikawa, Y Hosoe, E Nakamura, A Sugiyama, M Mandai, I Konishi, N Matsumura Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation Nat Commun, 2018-04-27;9(1):1685. 2018-04-27 [PMID: 29703902] (Mouse)
• H Wu, X Xu, J Li, J Gong, M Li TIM?4 blockade of KCs combined with exogenous TGF?β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts Int. J. Mol. Med., 2018-03-30;0(0):. 2018-03-30 [PMID: 29620252] (Mouse)
• Z Li, Y Wu, H Chen, C Zhu, L Dong, Y Wang, H Liu, X Xu, J Zhou, Y Wu, W Li, S Ying, H Shen, Z Chen MTOR Suppresses Environmental Particle-Induced Inflammatory Response in Macrophages J. Immunol., 2018-03-21;0(0):. 2018-03-21 [PMID: 29563176] (Mouse)
• C Laflamme, GB Mailhot, M Pouliot Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor Aging (Albany NY), 2017-10-18;9(10):2083-2097. 2017-10-18 [PMID: 29064819] (Mouse)
• L Mahdi, H Musafer, L Zwain, I Salman, I Al-Joofy, K Rasool, A Mussa, S Al-Kakei, R Al-Oqaili, S Al-Alak, A Chaloob, A Abdulkaree, B Hussein, N Mahdi, N Taher Two novel roles of buffalo milk lactoperoxidase, antibiofilm agent and immunomodulator against multidrug resistant Salmonella enterica serovar Typhi and Listeria monocytogenes Microb. Pathog., 2017-06-03;0(0):. 2017-06-03 [PMID: 28587762] (Mouse)
• RS Khambata, SM Ghosh, KS Rathod, T Thevathasa, F Filomena, Q Xiao, A Ahluwalia Antiinflammatory actions of inorganic nitrate stabilize the atherosclerotic plaque Proc. Natl. Acad. Sci. U.S.A, 2017-01-05;0(0):. 2017-01-05 [PMID: 28057862] (Mouse)
• Jill A Poole Systemic IL-6 Effector Response in Mediating Systemic Bone Loss Following Inhalation of Organic Dust J. Interferon Cytokine Res., 2016-11-22;0(0):. 2016-11-22 [PMID: 27875664] (Mouse)
• Vladimir R Muzykantov Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury FASEB J., 2016-11-11;0(0):. 2016-11-11 [PMID: 27836986] (Mouse)
• Plasminogen activator inhibitor-1 does not contribute to the pulmonary pathology induced by acute exposure to ozone Physiol Rep, 2016-09-01;4(18):. 2016-09-01 [PMID: 27670409] (Mouse)
• Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss PLoS ONE, 2016-08-01;11(8):e0158735. 2016-08-01 [PMID: 27479208] (Mouse)
• Daniel Hsu CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention Infect Immun, 2016-08-19;0(0):. 2016-08-19 [PMID: 27271746] (Mouse)
• CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin Eur J Immunol, 2016-06-08;0(0):. 2016-06-08 [PMID: 27184067] (Mouse)
• S Nakamura, N Iwanaga, M Seki, K Fukudome, K Oshima, T Miyazaki, K Izumikawa, K Yanagihara, Y Miyazaki, H Mukae, S Kohno Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice Infect Immun, 2016-06-23;0(0):. 2016-06-23 [PMID: 27091927] (Mouse)
• Chang S, Linderholm A, Harper R DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS ONE, 2015-07-06;10(7):e0131810. 2015-07-06 [PMID: 26148206] (Mouse)
• Lu H, Poirier C, Cook T, Traktuev D, Merfeld-Clauss S, Lease B, Petrache I, March K, Bogatcheva N Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis. J Transl Med, 2015-02-21;13(0):67. 2015-02-21 [PMID: 25889857] (Mouse)
• Dugan J, Griffiths E, Snow P, Rosenzweig H, Lee E, Brown B, Carr D, Rose C, Rosenbaum J, Davey M Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice. J Immunol, 2014-11-26;194(1):349-57. 2014-11-26 [PMID: 25429073] (Mouse)
• Zhang S, Luo L, Wang Y, Gomez M, Thorlacius H Nuclear factor of activated T cells regulates neutrophil recruitment, systemic inflammation, and T-cell dysfunction in abdominal sepsis. Infect Immun, 2014-05-27;82(8):3275-88. 2014-05-27 [PMID: 24866796] (Mouse)
• Huang Z, Zhao C, Chen Y, Cowell J, Wei G, Kultti A, Huang L, Thompson C, Rosengren S, Frost G, Shepard H Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation. J Immunol, 2014-04-28;192(11):5285-95. 2014-04-28 [PMID: 24778442] (Mouse)
• Tancevski I, Nairz M, Duwensee K, Auer K, Schroll A, Heim C, Feistritzer C, Hoefer J, Gerner R, Moschen A, Heller I, Pallweber P, Li X, Theurl M, Demetz E, Wolf A, Wolf D, Eller P, Ritsch A, Weiss G Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2. EMBO Mol Med, 2014-04-06;6(6):810-20. 2014-04-06 [PMID: 24755316] (Mouse)
• McKenzie C, Kim M, Singh T, Milev Y, Freedman J, Semple J Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI). Blood, 2014-03-17;123(22):3496-503. 2014-03-17 [PMID: 24637362] (Mouse)
• Liu Q, Tan Q, Zheng Y, Chen K, Qian C, Li N, Wang Q, Cao X Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation. J Biol Chem, 2014-03-13;289(16):11522-35. 2014-03-13 [PMID: 24627480] (Mouse)
• Mochizuki Y, Suzuki T, Oka N, Zhang Y, Hayashi Y, Hayashi N, Gotoh N, Ohashi Y Pseudomonas aeruginosa MucD protease mediates keratitis by inhibiting neutrophil recruitment and promoting bacterial survival. Invest Ophthalmol Vis Sci, 2014-01-09;55(1):240-6. 2014-01-09 [PMID: 24255043] (Mouse)
• Greineder , Colin F, Chacko , Ann-Mari, Zaytsev , Sergei, Zern , Blaine J, Carnemolla , Ronald, Hood , Elizabet, Han , Jingyan, Ding , Bi-Sen, Esmon , Charles, Muzykantov , Vladimir Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. PLoS ONE, 2013-11-14;8(11):e80110. 2013-11-14 [PMID: 24244621] (Mouse)
• Jablonska J, Wu C, Andzinski L, Leschner S, Weiss S CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-beta. Int J Cancer, 2013-10-31;134(6):1346-58. 2013-10-31 [PMID: 24154944] (Mouse)
• Hoehlig , Kai, Maasch , Christia, Shushakova , Nelli, Buchner , Klaus, Huber-Lang , Markus, Purschke , Werner G, Vater , Axel, Klussmann , Sven A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis. Mol Ther, 2013-07-26;21(12):2236-46. 2013-07-26 [PMID: 23887360] (Mouse)
• Merza M, Wetterholm E, Zhang S, Regner S, Thorlacius H Inhibition of geranylgeranyltransferase attenuates neutrophil accumulation and tissue injury in severe acute pancreatitis. J Leukoc Biol, 2013-06-06;94(3):493-502. 2013-06-06 [PMID: 23744643] (Mouse)
• Linke M, Ashbaugh A, Collins M, Lynch K, Cushion M Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infect Immun, 2013-01-14;81(3):984-95. 2013-01-14 [PMID: 23319554] (Mouse)
• Reddy A, Lakshmi S, Kleinhenz J, Sutliff R, Hart C, Reddy R Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury. J Immunol, 2012-10-26;189(11):5411-20. 2012-10-26 [PMID: 23105142] (Mouse)
• Ylostalo J, Bartosh T, Coble K, Prockop D Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells, 2012-10-01;30(10):2283-96. 2012-10-01 [PMID: 22865689] (Mouse)
• Ishii M, Asano K, Namkoong H, Tasaka S, Mizoguchi K, Asami T, Kamata H, Kimizuka Y, Fujiwara H, Funatsu Y, Kagawa S, Miyata J, Ishii K, Nakamura M, Hirai H, Nagata K, Kunkel SL, Hasegawa N, Betsuyaku T CRTH2 Is A Critical Regulator of Neutrophil Migration and Resistance to Polymicrobial Sepsis. J. Immunol., 2012-04-27;188(11):5655-64. 2012-04-27 [PMID: 22544936] (Mouse)
• Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury. J. Cell. Sci., 2012-03-16;91(6):921-32. 2012-03-16 [PMID: 22427680] (Mouse)
• Gottfries J, Melgar S, Michaelsson E Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease. PLoS ONE, 2012-01-18;7(1):e30005. 2012-01-18 [PMID: 22279558] (Mouse)
• Awla D, Abdulla A, Syk I, Jeppsson B, Regner S, Thorlacius H Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis. J. Leukoc. Biol., 2011-11-18;91(5):711-9. 2011-11-18 [PMID: 22100390] (Mouse)
• Walsh KB, Teijaro JR, Wilker PR Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Proc. Natl. Acad. Sci. U.S.A., 2011-06-29;108(29):12018-23. 2011-06-29 [PMID: 21715659] (Mouse)
• Koroskenyi K, Duro E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation. J. Immunol., 2011-05-18;186(12):7144-55. 2011-05-18 [PMID: 21593381] (Mouse)
• Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. J. Lipid Res., 2011-04-26;52(7):1307-18. 2011-04-26 [PMID: 21521824] (Mouse)
• Jang JE, Hod EA, Spitalnik SL CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. J. Clin. Invest., 2011-03-07;121(4):1397-401. 2011-03-07 [PMID: 21383500] (Mouse)
• Mendez MP, Monroy YK, Du M Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia. Respir. Res., 2011-01-19;12(1):12. 2011-01-19 [PMID: 21247482] (Mouse)
• Lee JS, Su X, Rackley C, Matthay MA, Gupta N Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken), 2010-11-16;294(1):165-72. 2010-11-16 [PMID: 21157927] (Mouse)
• Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J. Immunol., 2010-11-22;186(1):556-62. 2010-11-22 [PMID: 21098223] (Mouse)
• Dessing MC, Butter LM, Teske GJ S100A8/A9 is not involved in host defense against murine urinary tract infection. PLoS ONE, 2010-10-14;5(10):e13394. 2010-10-14 [PMID: 20976233] (Mouse)
• Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model. J. Immunol., 2010-09-15;185(8):4554-60. 2010-09-15 [PMID: 20844202] (Mouse)
• Kai-Larsen Y, Luthje P, Chromek M, Peters V, Wang X, Holm A, Kadas L, Hedlund KO, Johansson J, Chapman MR, Jacobson SH, Romling U, Agerberth B, Brauner A Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37. PLoS Pathog., 2010-07-22;6(0):e1001010. 2010-07-22 [PMID: 20661475] (Mouse)
• Fung YL, Kim M, Tabuchi A Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury. Blood, 2010-07-08;116(16):3073-9. 2010-07-08 [PMID: 20616220] (Mouse)
• Shiratori M, Tozaki-Saitoh H, Yoshitake M P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J. Neurochem., 2010-05-13;114(3):810-9. 2010-05-13 [PMID: 20477948] (Mouse)
• Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J. Clin. Invest., 2010-04-12;120(5):1645-62. 2010-04-12 [PMID: 20389019] (Mouse)
• Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA TLR4 is a negative regulator in noninfectious lung inflammation. J. Immunol., 2010-03-31;184(9):5308-14. 2010-03-31 [PMID: 20357263] (Mouse)
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• Fulton SA, Reba SM, Martin TD, Boom WH Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect. Immun., 2002-09-01;70(9):5322-7. 2002-09-01 [PMID: 12183593] (Mouse)
• Ghio AJ, 107303, Suliman HB, Carter JD, Abushamaa AM, Folz RJ Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8, 2002-07-01;283(1):L211-8. 2002-07-01 [PMID: 12060579] (Mouse)
• Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med., 2001-08-20;194(4):519-27. 2001-08-20 [PMID: 11514607] (Mouse)
• Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol., 2001-07-01;31(7):2104-15. 2001-07-01 [PMID: 11449364] (Mouse)
• Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity, 2001-06-01;14(6):705-14. 2001-06-01 [PMID: 11420041] (Mouse)
• Knott PG, Gater PR, Dunford PJ, Fuentes ME, Bertrand CP Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. J. Immunol., 2001-01-15;166(2):1233-40. 2001-01-15 [PMID: 11145706] (Mouse)
• Medvedev AE, Kopydlowski KM, Vogel SN Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J. Immunol., 2000-06-01;164(11):5564-74. 2000-06-01 [PMID: 10820230] (Mouse)

Bioinformatics

• Gene Symbol: Cxcl2