Human CCL21/6Ckine DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CCL21/6Ckine DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CCL21

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL21/6Ckine DuoSet ELISA, 15 Plate

• 6Ckine
• 6CkineSmall-inducible cytokine A21
• Beta-chemokine exodus-2
• CCL21
• chemokine (C-C motif) ligand 21
• CKb9
• exodus-2
• member 21
• SCYA21
• SCYA21MGC34555
• secondary lymphoid tissue chemokine
• SLC
• SLCSecondary lymphoid-tissue chemokine
• TCA-4

Background

CCL21, also known as 6Ckine, TCA-4, SLC, Exodus-2, and A21, is a homeostatic chemokine that signals through CCR7 or CXCR3. CCL21 is constitutively presented on initial lymphatic vessels, high endothelial venules (HEV), and lymph node dendritic cells (DC) where it promotes the docking of DC to lymphatic vessels and the retention of T cells by lymph node DC, resulting in T cell priming for activation. Its upregulation during chronic inflammation or tissue damage promotes fibrosis, inflammatory cytokine production, and neuropathic pain. The soluble chemokine is elevated in rheumatoid arthritis synovial fluid and in the serum of coronary artery disease patients.

Publications for CCL21/6Ckine (DY366)(13)

Publications using DY366

• W Alturaiki, H Alkadi, S Alamri, ME Awadalla, A Alfaez, A Mubarak, MA Alanazi, FQ Alenzi, BF Flanagan, B Alosaimi Association between the expression of Toll-like receptors, cytokines, and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 severity Heliyon, 2022-12-24;0(0):e12653. 2022-12-24 [PMID: 36589720] (Human)
• J Cao, EM Novoa, Z Zhang, WCW Chen, D Liu, GCG Choi, ASL Wong, C Wehrspaun, M Kellis, TK Lu High-throughput 5' UTR engineering for enhanced protein production in non-viral gene therapies Nature Communications, 2021-07-06;12(1):4138. 2021-07-06 [PMID: 34230498] (Human)
• X Guo, T Xu, J Zheng, X Cui, M Li, K Wang, M Su, H Zhang, K Zheng, C Sun, S Song, H Liu Accumulation of synovial fluid CD19+CD24hiCD27+ B cells was associated with bone destruction in rheumatoid arthritis Sci Rep, 2020-09-01;10(1):14386. 2020-09-01 [PMID: 32873834] (Human)
• J Bourland, J Fradette, FA Auger Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development Sci Rep, 2018-09-04;8(1):13191. 2018-09-04 [PMID: 30181613] (Human)
• L Strasser, HH Dang, H Schwarz, C Asam, F Ferreira, J Horejs-Hoe, CG Huber Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells Sci Rep, 2017-11-30;7(1):16638. 2017-11-30 [PMID: 29192156] (Human)
• J Lee, C Park, HJ Kim, YD Lee, ZH Lee, YW Song, HH Kim Stimulation of osteoclast migration and bone resorption by C-C chemokine ligands 19 and 21 Exp. Mol. Med., 2017-07-21;49(7):e358. 2017-07-21 [PMID: 28729639] (Human)
• Astrup E, Janardhanan J, Otterdal K, Ueland T, Prakash J, Lekva T, Strand O, Abraham O, Thomas K, Damas J, Mathews P, Mathai D, Aukrust P, Varghese G Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality. PLoS Negl Trop Dis, 2014-02-06;8(2):e2648. 2014-02-06 [PMID: 24516677] (Human)
• Pranzatelli , Michael, Tate , Elizabet, McGee , Nathan R, Travelstead , Anna L, Colliver , Jerry A, Ness , Jayne M, Ransohoff , Richard BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy. J Neuroinflammation, 2013-01-16;10(0):10. 2013-01-16 [PMID: 23324534] (Human)
• Vujanovic , Lazar, Ballard , Wenners, Thorne , Stephen, Vujanovic , Nikola L, Butterfield , Lisa H Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10. Oncoimmunology, 2012-07-01;1(4):448-457. 2012-07-01 [PMID: 22754763] (Human)
• Quesnel C, Piednoir P, Gelly J, Nardelli L, Garnier M, Lecon V, Lasocki S, Bouadma L, Philip I, Elbim C, Mentre F, Soler P, Crestani B, Dehoux M Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury. Crit. Care Med., 2012-01-01;40(1):21-8. 2012-01-01 [PMID: 21926612] (Human)
• Zimmer A, Luce S, Gaignier F, Nony E, Naveau M, Biola-Vidamment A, Pallardy M, Van Overtvelt L, Mascarell L, Moingeon P Identification of a New Phenotype of Tolerogenic Human Dendritic Cells Induced by Fungal Proteases from Aspergillus oryzae. J. Immunol., 2011-03-02;186(7):3966-76. 2011-03-02 [PMID: 21368225] (Human)
• Johnson LA, Jackson DG Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration. Int. Immunol., 2010-08-25;22(10):839-49. 2010-08-25 [PMID: 20739459] (Human)
• Toulza F, Nosaka K, Tanaka Y Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells. J. Immunol., 2010-06-04;185(1):183-9. 2010-06-04 [PMID: 20525891] (Human)

FAQs for CCL21/6Ckine (DY366). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: CCL21