Human CCL17/TARC Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human CCL17/TARC Quantikine ELISA Kit Summary

• Background: The Quantikine Human TARC Immunoassay kit is a 3.5 hour solid phase ELISA designed to measure TARC in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human TARC and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant human TARC. Results obtained using natural human TARC showed linear curves th...at were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human TARC.
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• Specificity: Natural and recombinant human TARC
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CCL17

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL17/TARC Quantikine ELISA Kit

• ABCD-2
• CC chemokine TARC
• C-C motif chemokine 17
• CCL17
• chemokine (C-C motif) ligand 17
• MGC138273
• SCYA17
• SCYA17MGC138271
• small inducible cytokine subfamily A (Cys-Cys), member 17
• Small-inducible cytokine A17
• T cell-directed CC chemokine
• TARC
• TARCA-152E5.3
• Thymus and activation-regulated chemokine

Background

CCL17/TARC is a chemokine that interacts with CCR4 and CCR8 to induce the chemoattraction of activated Th2 cells, basophils, and NK cells. It is produced by thymic dendritic cells, lymph node dendritic cells, monocytes, CD4+ T cells, keratinocytes, fibroblasts, bronchial epithelial cells, and Reed-Sternberg cells. CCL17 promotes Th2 cell recruitment to sites of inflammation and induces platelet aggregation and degranulation.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL17/TARC (DDN00)(41)

Publications using DDN00

• P Huang, F Hu, ZB Yang, Y Pan, R Zhou, YN Yan, HZ Wang, C Wang Matrine regulates Th1/Th2 inflammatory responses by inhibiting the Hsp90/NF-kappaB signaling axis to alleviate atopic dermatitis The Kaohsiung journal of medical sciences, 2023-02-09;0(0):. 2023-02-09 [PMID: 36757049] (Mouse)
• SI Johanns, RG Gantin, B Wangala, K Komlan, WA Halatoko, M Banla, P Karabou, AJ Luty, H Schulz-Key, C Köhler, PT Soboslay Onchocerca volvulus-specific antibody and cellular responses in onchocerciasis patients treated annually with ivermectin for 30 years and exposed to parasite transmission in central Togo PloS Neglected Tropical Diseases, 2022-05-03;16(5):e0010340. 2022-05-03 [PMID: 35503786] (Human)
• A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 PloS Pathogens, 2022-01-13;18(1):e1010200. 2022-01-13 [PMID: 35025968] (Human)
• L Kobari, M Auclair, O Piau, N Ferrand, M Zaoui, F Delhommeau, B Fève, M Sabbah, L Garderet Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells Leukemia, 2021-09-23;0(0):. 2021-09-23 [PMID: 34556797] (Human)
• L Qiu, L Zhang, R Qi, X Gao, H Chen, T Xiao miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid Dis. Markers, 2020-01-11;2020(0):9505312. 2020-01-11 [PMID: 32399091] (Human)
• A Nikonova, M Khaitov, DJ Jackson, S Traub, MB Trujillo-T, DA Kudlay, AS Dvornikov, A Del-Rosari, R Valenta, LA Stanciu, R Khaitov, SL Johnston M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations EBioMedicine, 2020-04-09;54(0):102734. 2020-04-09 [PMID: 32279057] (Human)
• O Gidlöf, M Evander, M Rezeli, G Marko-Varg, T Laurell, D Erlinge Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone Sci Rep, 2019-06-20;9(1):8991. 2019-06-20 [PMID: 31222168] (Human)
• D Bao, J Zhao, X Zhou, Q Yang, Y Chen, J Zhu, P Yuan, J Yang, T Qin, S Wan, J Xing Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression Oncogene, 2019-03-20;0(0):. 2019-03-20 [PMID: 30894684] (Human)
• TD Jung, SI Choi, SH Choi, BY Cho, WS Sim, SJ Lee, SJ Park, DB Kim, YC Kim, JH Lee, OH Lee Changes in the Anti-Allergic Activities of Sesame by Bioconversion Nutrients, 2018-02-14;10(2):. 2018-02-14 [PMID: 29443928] (Human)
• Jae Sung Hwang Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid Biomol Ther (Seoul), 2016-09-01;24(5):529-35. 2016-09-01 [PMID: 27169822] (Human)
• Shi G, Han J, Liu G, Hao Y, Ma Y, Li T, Wu X, Zhang H, Liu Y, Wang B, Kong Y, Zhou J, Zeng H Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients. Eur J Immunol, 2013-12-02;44(2):420-30. 2013-12-02 [PMID: 24155161] (Human)
• Marri P, Hodge L, Maurer M, Ziesmer S, Slager S, Habermann T, Link B, Cerhan J, Novak A, Ansell S Prognostic significance of pretreatment serum cytokines in classical Hodgkin lymphoma. Clin Cancer Res, 2013-10-18;19(24):6812-9. 2013-10-18 [PMID: 24141626] (Human)
• Pranzatelli , Michael, Tate , Elizabet, McGee , Nathan R, Travelstead , Anna L, Colliver , Jerry A, Ness , Jayne M, Ransohoff , Richard BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy. J Neuroinflammation, 2013-01-16;10(0):10. 2013-01-16 [PMID: 23324534] (Human)
• Rai AK, Thakur CP, Singh A Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis. PLoS ONE, 2012-02-08;7(2):e31551. 2012-02-08 [PMID: 22347492] (Human)
• Younes A, Bartlett NL, Leonard JP Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N. Engl. J. Med., 2010-11-04;363(19):1812-21. 2010-11-04 [PMID: 21047225] (Human)
• Roufosse F, de Lavareille A, Schandene L, Cogan E, Georgelas A, Wagner L, Xi L, Raffeld M, Goldman M, Gleich GJ, Klion A Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome. J. Allergy Clin. Immunol., 2010-10-01;126(4):828-835. 2010-10-01 [PMID: 20810155] (Human)
• Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J. Immunol., 2010-02-17;184(6):2886-98. 2010-02-17 [PMID: 20164417] (Human)
• Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis. Mediators Inflamm., 2009-07-22;2009(0):269541. 2009-07-22 [PMID: 19639049] (Human)
• Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. J. Allergy Clin. Immunol., 2009-06-27;124(2):260-9, 269.e1. 2009-06-27 [PMID: 19541356] (Human)
• Cornforth AN, Lee GJ, Fowler AW, Carbonell DJ, Dillman RO Increases in serum TARC/CCL17 levels are associated with progression-free survival in advanced melanoma patients in response to dendritic cell-based immunotherapy. J. Clin. Immunol., 2009-05-07;29(5):657-64. 2009-05-07 [PMID: 19421847] (Human)
• Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22. J. Interferon Cytokine Res., 2008-05-01;28(5):297-310. 2008-05-01 [PMID: 18547160] (Human)
• Miller R, Sadhukhan R, Wu C Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods, 2008-03-07;334(1):134-41. 2008-03-07 [PMID: 18355834] (Human)
• Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, Van Den Berg A Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes. Blood, 2007-12-10;111(4):2339-46. 2007-12-10 [PMID: 18070985] (Human)
• Haas J, Schopp L, Storch-Hagenlocher B, Fritzsching B, Jacobi C, Milkova L, Fritz B, Schwarz A, Suri-Payer E, Hensel M, Wildemann B Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis. Blood, 2007-10-29;111(2):761-6. 2007-10-29 [PMID: 17967942] (Human)
• Barrera L, Mendoza F, Zuniga J, Estrada A, Zamora AC, Melendro EI, Ramirez R, Pardo A, Selman M Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis. Am. J. Respir. Crit. Care Med., 2007-10-18;177(1):44-55. 2007-10-18 [PMID: 17947613] (Human)
• Latzin P, Hartl D, Regamey N, Frey U, Schoeni MH, Casaulta C Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. Eur. Respir. J., 2007-09-26;31(1):36-42. 2007-09-26 [PMID: 17898016] (Human)
• Miyazaki E, Nureki S, Ono E, Ando M, Matsuno O, Fukami T, Ueno T, Kumamoto T Circulating thymus- and activation-regulated chemokine/CCL17 is a useful biomarker for discriminating acute eosinophilic pneumonia from other causes of acute lung injury. Chest, 2007-06-01;131(6):1726-34. 2007-06-01 [PMID: 17565019] (Human)
• Heijink IH, Marcel Kies P, van Oosterhout AJ, Postma DS, Kauffman HF, Vellenga E Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium. Am. J. Respir. Cell Mol. Biol., 2006-10-05;36(3):351-9. 2006-10-05 [PMID: 17023689] (Human)
• Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. Acta Derm. Venereol., 2006-01-01;86(5):393-8. 2006-01-01 [PMID: 16955181] (Human)
• Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands. J. Immunol., 2006-05-15;176(10):5760-71. 2006-05-15 [PMID: 16670281] (Human)
• Hartl D, Latzin P, Zissel G, Krane M, Krauss-Etschmann S, Griese M Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med., 2006-03-16;173(12):1370-6. 2006-03-16 [PMID: 16543550] (Human)
• Leung TF, Wong GW, Ko FW, Lam CW, Fok TF Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma. Clin. Exp. Allergy, 2004-05-01;34(5):786-91. 2004-05-01 [PMID: 15144472] (Human)
• Hon KL, Leung TF, Ma KC, Li AM, Wong Y, Fok TF Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin. Exp. Dermatol., 2004-05-01;29(3):293-6. 2004-05-01 [PMID: 15115514] (Human)
• Narikawa K, Misu T, Fujihara K, Nakashima I, Sato S, Itoyama Y CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis. J. Neuroimmunol., 2004-04-01;149(1):182-6. 2004-04-01 [PMID: 15020078] (Human)
• Leung TF, Ng PC, Tam WH, Li CY, Wong E, Ma TP, Lam CW, Fok TF Helper T-lymphocyte-related chemokines in healthy newborns. Pediatr. Res., 2003-11-19;55(2):334-8. 2003-11-19 [PMID: 14630994] (Human)
• Xiao T, Fujita H, Saeki H, Mitsui H, Sugaya M, Tada Y, Kakinuma T, Torii H, Nakamura K, Asahina A, Tamaki K Thymus and activation-regulated chemokine (TARC/CCL17) produced by mouse epidermal Langerhans cells is upregulated by TNF-alpha and IL-4 and downregulated by IFN-gamma. Cytokine, 2003-08-01;23(4):126-32. 2003-08-01 [PMID: 12967648] (Human)
• Matsumoto N, Mukae H, Nakamura-Uchiyama F, Ashitani JI, Abe K, Katoh S, Kohno S, Nawa Y, Matsukura S Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with Paragonimus westermani. Clin. Exp. Immunol., 2002-11-01;130(2):314-8. 2002-11-01 [PMID: 12390321] (Human)
• D'Ambrosio D Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes. Eur. J. Immunol., 2002-10-01;32(10):2934-43. 2002-10-01 [PMID: 12355447] (Human)
• Novak N, Allam P, Geiger E, Bieber T Characterization of monocyte subtypes in the allergic form of atopic eczema/dermatitis syndrome. Allergy, 2002-10-01;57(10):931-5. 2002-10-01 [PMID: 12269940] (Human)
• Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, Girolomoni G A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J. Leukoc. Biol., 2001-10-01;70(4):617-23. 2001-10-01 [PMID: 11590199] (Human)
• de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. Eur. J. Immunol., 2001-04-01;31(4):1037-46. 2001-04-01 [PMID: 11298328] (Human)

FAQs for CCL17/TARC (DDN00). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: CCL17