Human C-Reactive Protein/CRP Quantikine ELISA Kit



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Human C-Reactive Protein/CRP Quantikine ELISA Kit Summary

The Quantikine Human CRP Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CRP in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human CRP and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CRP showed linear curves that were parallel to the standard curves obtained using the Quantikin...e kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CRP.
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Additional Information
This kit is in the process of being discontinued.
Natural and recombinant human CRP
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using
DCRP00 in the following applications:

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human C-Reactive Protein/CRP Quantikine ELISA Kit

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895


C-Reactive Protein (CRP), also known as Pentraxin 1, is a non-glycosylated protein in the Pentraxin family that also includes Pentraxin 2/SAP and Pentraxin 3/TSG-14. CRP functions as a sensor and activator of the innate immune response (1). In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation (2). In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2 (3). CRP assembles non-covalently into a 110-120 kDa cyclical pentamer (4). Mature human CRP shares 71% and 64% amino acid (aa) sequence identity with mouse and rat CRP, respectively (5). 
CRP binds and opsonizes apoptotic cells (6-8) as well as bacteria such as S. pneumoniae (9, 10). It subsequently enhances the phagocytosis of these opsonized cells (6, 8-10). CRP additionally binds several proteins in the complement cascade including C1q, C4BP, and Factor H (8, 11-13). It enhances activation of the classical complement pathway and the deposition of C3b (9). In later stages of the response, CRP inhibits complement-mediated cell lysis through its binding to C4BP and Factor H (8, 12). These interactions induce the upregulation of complement inhibitory proteins CD46, CD59, and CD55/DAF and inhibit assembly of the membrane attack complex (MAC) (8, 14). 
CRP binds to Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells (15-17), and Fc receptors are required for the phagocytosis of CRP-opsonized target cells (6, 10, 18). CRP binding to Fc gamma RI induces Src activation which subsequently triggers the inhibitory Fc gamma RIIb and dampens the inflammatory response (15, 19). CRP additionally promotes dendritic cell maturation and humoral immunity (10). In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in coronary artery infarction, and inhibits the repair of injured vascular endothelium (7, 19, 20). 

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for C-Reactive Protein/CRP (DCRP00)(137)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 1 application: ELISA Capture.

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Showing Publications 1 - 10 of 137. Show All 137 Publications.
Publications using DCRP00 Applications Species
Stewart, JC;Patel, JS;Polanka, BM;Gao, S;Nurnberger, JI;MacDonald, KL;Gupta, SK;Considine, RV;Kovacs, RJ;Vrany, EA;Berntson, J;Hsueh, L;Shell, AL;Rollman, BL;Callahan, CM; Effect of Modernized Collaborative Care for Depression on Depressive Symptoms and Cardiovascular Disease Risk Biomarkers: eIMPACT Randomized Controlled Trial Brain, behavior, and immunity 2023-05-18 [PMID: 37209779] (Human) Human
N Subramania, K Hofwimmer, B Tavira, L Massier, DP Andersson, P Arner, J Laurenciki Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells Cardiovascular Diabetology, 2023-04-12;22(1):84. 2023-04-12 [PMID: 37046242] (Human) Human
H Hallihan, P Tsai, N Lv, L Xiao, B Peñalver B, Y Wu, GN Pandey, LM Williams, OA Ajilore, J Ma Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity Journal of psychiatric research, 2023-02-03;160(0):9-18. 2023-02-03 [PMID: 36764197] (Human) Human
X Luo, Z Fang, L Lin, H Xu, Q Huang, H Zhang Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma BMC Psychiatry, 2022-11-29;22(1):741. 2022-11-29 [PMID: 36447174] (Human) Human
AH Cincotta, E Cersosimo, M Alatrach, M Ezrokhi, C Agyin, J Adams, R Chilton, C Triplitt, B Chamarthi, N Cominos, RA DeFronzo Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects International Journal of Molecular Sciences, 2022-08-09;23(16):. 2022-08-09 [PMID: 36012132] (Human) Human
S Mahgoub, SS Fatahala, AI Sayed, HB Atya, MF El-Shehry, H Afifi, SM Awad, RHA El-Hameed, H Taha Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19 Bioorganic chemistry, 2022-08-10;128(0):106092. 2022-08-10 [PMID: 35985159] (Human) Human
H Svensson, S Einarsson, D Olausson, L Kluge, C Bergh, S Edén, M Lönn, A Thurin-Kje Inflammatory and metabolic markers in relation to outcome of in vitro fertilization in a cohort of predominantly overweight and obese women Scientific Reports, 2022-08-03;12(1):13331. 2022-08-03 [PMID: 35922472] (Human) Human
LS Silva-Berm, A Vargas-Vil, CA Sánchez-Va, AC Palacio, AF Buitrago, CO Mendivil Peri-event plasma PCSK9 and hsCRP after an acute myocardial infarction correlate with early deterioration of left ventricular ejection fraction: a cohort study Oncogene, 2022-07-21;21(1):61. 2022-07-21 [PMID: 35864531] (Human) Human
MS Simon, BB Barton, C Glocker, R Musil A comprehensive approach to predicting weight gain and therapy response in psychopharmacologically treated major depressed patients: A cohort study protocol PLoS ONE, 2022-07-21;17(7):e0271793. 2022-07-21 [PMID: 35862413] (Human) Human
R Basiri, M Spicer, C Levenson, T Ledermann, N Akhavan, B Arjmandi Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers Nutrients, 2022-06-09;14(12):. 2022-06-09 [PMID: 35745123] (Human) Human
Show All 137 Publications.

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Gene Symbol CRP