Human C-Reactive Protein/CRP Quantikine ELISA Kit

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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human C-Reactive Protein/CRP Quantikine ELISA Kit Summary

Background
The Quantikine Human CRP Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CRP in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human CRP and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CRP showed linear curves that were parallel to the standard curves obtained using the Quantikin...e kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CRP.
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Specificity
Natural and recombinant human CRP
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CRP

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
DCRP00 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human C-Reactive Protein/CRP Quantikine ELISA Kit

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895

Background

C-Reactive Protein (CRP), also known as Pentraxin 1, is a non-glycosylated protein in the Pentraxin family that also includes Pentraxin 2/SAP and Pentraxin 3/TSG-14. CRP functions as a sensor and activator of the innate immune response (1). In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation (2). In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2 (3). CRP assembles non-covalently into a 110-120 kDa cyclical pentamer (4). Mature human CRP shares 71% and 64% amino acid (aa) sequence identity with mouse and rat CRP, respectively (5). 
CRP binds and opsonizes apoptotic cells (6-8) as well as bacteria such as S. pneumoniae (9, 10). It subsequently enhances the phagocytosis of these opsonized cells (6, 8-10). CRP additionally binds several proteins in the complement cascade including C1q, C4BP, and Factor H (8, 11-13). It enhances activation of the classical complement pathway and the deposition of C3b (9). In later stages of the response, CRP inhibits complement-mediated cell lysis through its binding to C4BP and Factor H (8, 12). These interactions induce the upregulation of complement inhibitory proteins CD46, CD59, and CD55/DAF and inhibit assembly of the membrane attack complex (MAC) (8, 14). 
CRP binds to Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells (15-17), and Fc receptors are required for the phagocytosis of CRP-opsonized target cells (6, 10, 18). CRP binding to Fc gamma RI induces Src activation which subsequently triggers the inhibitory Fc gamma RIIb and dampens the inflammatory response (15, 19). CRP additionally promotes dendritic cell maturation and humoral immunity (10). In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in coronary artery infarction, and inhibits the repair of injured vascular endothelium (7, 19, 20). 

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for C-Reactive Protein/CRP (DCRP00)(117)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 1 application: ELISA Capture.


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ELISA Capture
(1)
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Human
(114)
Mouse
(1)
Transgenic Mouse
(1)
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Showing Publications 1 - 10 of 117. Show All 117 Publications.
Publications using DCRP00 Applications Species
M Manzano, A Talavera-R, E Moreno, N Madrid, MJ Gosalbes, R Ron, F Dronda, JA Pérez-Moli, VF Lanza, J Díaz, S Moreno, B Navia, S Serrano-Vi Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV Nutrients, 2022;14(6):. 2022 [PMID: 35334878] (Human) Human
X Yang, R Dai, Z Qin, R Cai, Y Xu, Q Su LncRNA MALAT1 functions as a biomarker of no-reflow phenomenon in ST-segment elevation myocardial infarction patients receiving primary percutaneous coronary intervention Scientific Reports, 2022;12(1):3294. 2022 [PMID: 35228564] (Human) Human
SY Lee, TY Wang, RB Lu, LJ Wang, CH Chang, YC Chiang, CC Pan, KW Tsai Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder Journal of personalized medicine, 2021;11(12):. 2021 [PMID: 34945756] (Human) Human
HA Al-Rawaf, AH Alghadir, SA Gabr Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study BioMed Research International, 2021;2021(0):7453000. 2021 [PMID: 34917685] (Human) Human
C Griffen, M Duncan, J Hattersley, MO Weickert, A Dallaway, D Renshaw Effects of resistance exercise and whey protein supplementation on skeletal muscle strength, mass, physical function, and hormonal and inflammatory biomarkers in healthy active older men: A randomised, double-blind, placebo-controlled trial Experimental gerontology, 2021;0(0):111651. 2021 [PMID: 34896568] (Human) Human
NM Al-Daghri, S Abdi, S Sabico, AM Alnaami, KA Wani, MGA Ansari, MNK Khattak, N Khan, G Tripathi, GP Chrousos, PG McTernan Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes Biomolecules, 2021;11(11):. 2021 [PMID: 34827691] (Human) Human
EC Lefferts, BA Hibner, WK Lefferts, NS Lima, T Baynard, JM Haus, AD Lane-Cordo, SA Phillips, B Fernhall Oral vitamin C restores endothelial function during acute inflammation in young and older adults Physiological Reports, 2021;9(21):e15104. 2021 [PMID: 34762777] (Human) Human
HA Fachim, Z Iqbal, JM Gibson, I Baricevic-, AE Campbell, B Geary, AA Syed, A Whetton, H Soran, RP Donn, AH Heald Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery Cells, 2021;10(10):. 2021 [PMID: 34685777] (Human) Human
YK Pageot, AL Stanton, PA Ganz, MR Irwin, SW Cole, CM Crespi, EC Breen, KR Kuhlman, JE Bower Socioeconomic Status and Inflammation in Women with Early-stage Breast Cancer: Mediation by Body Mass Index Brain, Behavior, and Immunity, 2021;99(0):307-316. 2021 [PMID: 34673177] (Human) Human
R Nabatanzi, L Bayigga, S Cose, G Canderan, S Rowland Jo, M Joloba, D Nakanjako Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort BMC immunology, 2021;22(1):59. 2021 [PMID: 34445953] (Human) Human
Show All 117 Publications.

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Gene Symbol CRP