Human C-Reactive Protein/CRP Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human C-Reactive Protein/CRP Quantikine ELISA Kit Summary

Background
The Quantikine Human CRP Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CRP in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human CRP and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CRP showed linear curves that were parallel to the standard curves obtained using the Quantikin...e kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CRP.
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Specificity
Natural and recombinant human CRP
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CRP

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
DCRP00 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human C-Reactive Protein/CRP Quantikine ELISA Kit

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895

Background

C-Reactive Protein (CRP), also known as Pentraxin 1, is a non-glycosylated protein in the Pentraxin family that also includes Pentraxin 2/SAP and Pentraxin 3/TSG-14. CRP functions as a sensor and activator of the innate immune response (1). In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation (2). In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2 (3). CRP assembles non-covalently into a 110-120 kDa cyclical pentamer (4). Mature human CRP shares 71% and 64% amino acid (aa) sequence identity with mouse and rat CRP, respectively (5). 
CRP binds and opsonizes apoptotic cells (6-8) as well as bacteria such as S. pneumoniae (9, 10). It subsequently enhances the phagocytosis of these opsonized cells (6, 8-10). CRP additionally binds several proteins in the complement cascade including C1q, C4BP, and Factor H (8, 11-13). It enhances activation of the classical complement pathway and the deposition of C3b (9). In later stages of the response, CRP inhibits complement-mediated cell lysis through its binding to C4BP and Factor H (8, 12). These interactions induce the upregulation of complement inhibitory proteins CD46, CD59, and CD55/DAF and inhibit assembly of the membrane attack complex (MAC) (8, 14). 
CRP binds to Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells (15-17), and Fc receptors are required for the phagocytosis of CRP-opsonized target cells (6, 10, 18). CRP binding to Fc gamma RI induces Src activation which subsequently triggers the inhibitory Fc gamma RIIb and dampens the inflammatory response (15, 19). CRP additionally promotes dendritic cell maturation and humoral immunity (10). In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in coronary artery infarction, and inhibits the repair of injured vascular endothelium (7, 19, 20). 

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for C-Reactive Protein/CRP (DCRP00)(85)

We have publications tested in 2 confirmed species: Human, Transgenic Mouse.

We have publications tested in 1 application: ELISA Capture.


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ELISA Capture
(1)
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Human
(83)
Transgenic Mouse
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Showing Publications 1 - 10 of 85. Show All 85 Publications.
Publications using DCRP00 Applications Species
AM Andersen, MK Lei, SRH Beach, RA Philibert Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking Journal of psychosomatic research, 2020;141(0):110326. 2020 [PMID: 33310155] (Human) Human
LG D'Cruz, KG McEleney, C Cochrane, KBC Tan, P Shukla, PV Gardiner, D Small, SD Zhang, DS Gibson Assessment of a dried blood spot C-reactive protein method to identify disease flares in rheumatoid arthritis patients Scientific Reports, 2020;10(1):21089. 2020 [PMID: 33273485] (Human) Human
J Ma, Y Zhou, D Wang, Y Guo, B Wang, Y Xu, W Chen Associations between essential metals exposure and metabolic syndrome (MetS): Exploring the mediating role of systemic inflammation in a general Chinese population Environ Int, 2020;140(0):105802. 2020 [PMID: 32474217] (Human) Human
SP Polster, A Sharma, C Tanes, AT Tang, P Mericko, Y Cao, J Carrión-Pe, R Girard, J Koskimäki, D Zhang, A Stadnik, SG Romanos, SB Lyne, R Shenkar, K Yan, C Lee, A Akers, L Morrison, M Robinson, A Zafar, K Bittinger, H Kim, JA Gilbert, ML Kahn, L Shen, IA Awad Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma Nat Commun, 2020;11(1):2659. 2020 [PMID: 32461638] (Human) Human
S Guglielmet, S Bernardi, C Del Bo', A Cherubini, M Porrini, G Gargari, N Hidalgo-Li, R Gonzalez-D, G Peron, R Zamora-Ros, MS Winterbone, B Kirkup, PA Kroon, C Andres-Lac, P Riso Effect of a polyphenol-rich dietary pattern on intestinal permeability and gut and blood microbiomics in older subjects: study protocol of the MaPLE randomised controlled trial BMC Geriatr, 2020;20(1):77. 2020 [PMID: 32102662] (Human) Human
I Elisia, V Lam, B Cho, M Hay, MY Li, J Kapeluto, T Elliott, D Harris, L Bu, W Jia, H Leung, W Mohn, G Krystal Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk PLoS ONE, 2020;15(2):e0228633. 2020 [PMID: 32027700] (Human) Human
JF Camargo, S Pallikkuth, I Moroz, Y Natori, ML Alcaide, A Rodriguez, G Guerra, GW Burke, S Pahwa Pretransplant Levels of C-Reactive Protein,�Soluble TNF Receptor-1, and�CD38+HLADR+ CD8 T Cells Predict Risk of Allograft Rejection in HIV+ Kidney Transplant Recipients Kidney Int Rep, 2019;4(12):1705-1716. 2019 [PMID: 31844807] (Human) Human
A Picca, RT Mankowski, G Kamenov, SD Anton, TM Manini, TW Buford, SK Saini, R Calvani, F Landi, R Bernabei, E Marzetti, C Leeuwenbur Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle Cells, 2019;8(12):. 2019 [PMID: 31783583] (Human) Human
M Sotos-Prie, C Christophi, A Black, JD Furtado, Y Song, P Magiatis, A Papakonsta, E Melliou, S Moffatt, SN Kales Assessing Validity of Self-Reported Dietary Intake within a Mediterranean Diet Cluster Randomized Controlled Trial among US Firefighters Nutrients, 2019;11(9):. 2019 [PMID: 31546768] (Human) Human
TJ Wade, DD O'Leary, KS Dempster, AJ MacNeil, DS Molnar, J McGrath, J Cairney Adverse childhood experiences (ACEs) and cardiovascular development from childhood to early adulthood: study protocol of the Niagara Longitudinal Heart Study BMJ Open, 2019;9(7):e030339. 2019 [PMID: 31315878] (Human) Human
Show All 85 Publications.

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Product General Protocols

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FAQs for C-Reactive Protein/CRP (DCRP00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DCRP00
HRP DCRP00
HRP DCRP00

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Bioinformatics

Gene Symbol CRP