HSF4 Antibody (504524) [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 504524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

HSF4 Antibody (504524) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human HSF4
  Ser309-Pro463
  Accession # BAA13433
• Specificity: Detects endogenous human and mouse HSF4 in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HSF4 Antibody (504524) [Alexa Fluor® 350]

• ATHSF4
• AT-HSFB1
• cataract, Marner
• CTM
• heat shock factor protein 4
• heat shock transcription factor 4CTM
• hHSF4
• HSF 4
• HSF4
• HSFB1
• HSTF 4

Background

HSF4 (heat shock factor 4) is a 53 kDa member of the HSF family of transcription factors. It is highly expressed in the lens where it maintains lens integrity and blocks FGF synthesis. Human HSF4 has two isoforms HSF4B and HSF4A. Human HSF4B is 493 amino acids in length. It contains one DNA binding region (aa 18‑122) and two hydrophobic repeat domains A/B and C (aa 130‑204 and 369‑390). HSF4B activates transcription, whereas, HSF4A represses transcription. HSF4A shows a 45 aa substitution for aa 246‑320. Over aa 309‑463, human HSF4B shares 73% aa sequence identity with mouse HSF4B.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.