HSD11B2 Antibody

Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP1-39478] - Analysis of anti-HSD11B2 antibody with human kidney at concentration 10 ug/ml.

Product Discontinued

HSD11B2 Antibody Summary

• Immunogen: Synthetic peptide corresponding to aa 25-40 (R25SDLRLGRPLLAALAL40) of human HSD11B2.
• Epitope: aa 25-40 (R25SDLRLGRPLLAALAL40)
• Predicted Species: Porcine (94%), Bovine (94%), Rabbit (94%), Bat (94%), Sheep (94%), Monkey (100%), Primate (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HSD11B2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 1:200

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Equine (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS, pH 7.4, 50% glycerol, and 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for HSD11B2 Antibody

• 11 betaHSD2
• 11 beta-HSD2
• AME
• corticosteroid 11-beta-dehydrogenase isozyme 2,11-beta-HSD2
• EC 1.1.1
• EC 1.1.1.-
• HSD11B2
• HSD11KAME1
• HSD2,11-DH2
• hydroxysteroid (11-beta) dehydrogenase 2
• NAD-dependent 11-beta-hydroxysteroid dehydrogenase
• SDR9C3
• short chain dehydrogenase/reductase family 9C member 3,11-beta-hydroxysteroid dehydrogenase type 2

Background

HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HSD11B2 Antibody (NBP1-39478)(1)

Publication using NBP1-39478

• Liu H, Wang R, Zhu J et al. Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function Research Square 2023-09-01

Bioinformatics

• Gene Symbol: HSD11B2
• Entrez:
  • 3291(Human)
  • 15484(Mouse)
  • 25117(Rat)
• Uniprot:
  • P80365()