Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
3291 |
| Alternate Names |
- AME
- corticosteroid 11-beta-dehydrogenase isozyme 2,11-beta-HSD2
- EC 1.1.1
- EC 1.1.1.-
- HSD11KAME1
- HSD2,11-DH2
- hydroxysteroid (11-beta) dehydrogenase 2
- NAD-dependent 11-beta-hydroxysteroid dehydrogenase
- SDR9C3
- short chain dehydrogenase/reductase family 9C member 3,11-beta-hydroxysteroid dehydrogenase type 2
|
Research Areas for HSD11B2
Find related products by research area and learn more about each of the different research areas below.
Stem Cell Markers
![Western Blot HSD11B2 Antibody (921215) [Unconjugated]](http://images.novusbio.com/fullsize2/11_betaHSD2_MAB8630_Western_Blot_16837.jpg)
![Immunohistochemistry HSD11B2 Antibody (921215) [Unconjugated]](http://images.novusbio.com/fullsize2/11_betaHSD2_MAB8630_Immunohistochemistry_16831.jpg)
