HNF1 Antibody (4110) [Janelia Fluor® 646]

Product Discontinued

HNF1 Antibody (4110) [Janelia Fluor® 646] Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human HNF1. The exact sequence is proprietary.
• Predicted Species: Rat (99%), Porcine (99%), Bovine (98%), Chicken (95%). Backed by our 100% Guarantee.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: HNF1A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Xenopus laevis (85%).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for HNF1 Antibody (4110) [Janelia Fluor® 646]

• HNF1 homeobox A
• IDDM20
• LFB1transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albuminproximal factor
• MODY3
• TCF1hepatic
• Transcription factor 1

Background

TCF 1 (T cell factor 1) is a member of the TCF/LEF (lymphoid enhancer factor) family of transcription factors. Members of this family along with 226; catenin, are involved in mediating Wnt signaling by transactivating downstream genes. TCF 1 is closely related to LEF-1, both of which are transcription factors expressed in mice during T cell differentiation. They regulate the T cell receptor 225; enhancer in transfections assays. TCF 1 becomes transcriptionally active through interaction with 226; catenin. Also, numerous splice variants of TCF 1 have been identified. Overexpression of TCF-1-specific splice forms appears to correlate with the metastatic behavior of colorectal cancer cells and with overproduction of lymphoid tyrosine protein kinase p56(lck).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HNF1A