This product is unpurified. The exact concentration of antibody is not quantifiable.
This HIP1 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is observed at ~115 kDa. Use in Immunoprecipitation reported in scientific literature (PMID 23272104)
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Human, mouse and bacteria. Does not appear to work in rat.
Alternate Names for HIP1 Antibody (1B11)
huntingtin interacting protein 1
huntingtin-interacting protein 1
Huntingtin-interacting protein I
One of the four subunits of the histone regulatory complex A, HIP1 is an anti-apoptosis protein in the brain. HIP1 (Huntingtin-interacting protein 1) protects normal neurological tissue from erroneous inflammatory and apoptotic events by linking the actin cytoskeleton and clathrin-mediated endocytosis machinery. It is important in the generation of clathrin coated vesicles in the neuron. However, if deletion of HIP1 occurs, neurological disease is initiated and is correlated to epilepsy, learning disabilities, spinal and testicular defects, hematopoietic issues, and other neurobehavioral abnormalities such as Huntington's disease. HIP1 also interacts with the Hedgehog signaling pathway, and is important in regulating the abundance and scope of Hedgehog signaling.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.