HFE Antibody (HL2155)

Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with HFE antibody [HL2155] (NBP3-48673) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

• Reactivity: Hu
• Applications: WB
• Clone: HL2155
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

HFE Antibody (HL2155) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant protein encompassing a sequence within the Extracellular domain of human HFE. The exact sequence is proprietary.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: HFE
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:3000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Alternate Names for HFE Antibody (HL2155)

• dJ221C16.10.1
• hemochromatosis
• hereditary hemochromatosis protein HLA-H
• hereditary hemochromatosis protein
• HFE
• HFE1
• HH
• high Fe
• HLAH
• HLA-H
• HLA-HHFE1
• MGC103790
• MHC class I-like protein HFE
• MVCD7
• TFQTL2

Background

HFE is encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HFE