HERPUD1 Antibody (24GB14035)

• Reactivity: Hu, Mu, Rt
• Applications: WB, Mycoplasma
• Clone: 24GB14035
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

HERPUD1 Antibody (24GB14035) Summary

• Description: Reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.
• Immunogen: Recombinant protein of human HERPUD1 (Uniprot: Q15011)
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: HERPUD1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Knockdown Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for HERPUD1 Antibody (24GB14035)

• HERPMIF1
• homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-likedomain member 1 protein
• homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-likedomain member 1
• homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domainmember 1 protein
• KIAA0025MMS-inducible
• Methyl methanesulfonate (MMF)-inducible fragment protein 1
• Mif1
• SUP

Background

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HERPUD1