HERPUD1 Products

Description

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Bioinformatics

Entrez	64209 Mouse 9709 Human
Uniprot	AAH00086 Human AAH32673 Human NM_001010989 Human NM_014685 Human NP_055500 Human NP_055500.1 Human Q15011 Human
Product By Gene ID	9709
Alternate Names	HERPMIF1 homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-likedomain member 1 protein homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-likedomain member 1 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domainmember 1 protein KIAA0025MMS-inducible Methyl methanesulfonate (MMF)-inducible fragment protein 1 Mif1 SUP