Helios Antibody (736440) [Alexa Fluor® 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
736440
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 488
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Helios Antibody (736440) [Alexa Fluor® 488] Summary

Immunogen
E. coli-derived recombinant human Helios
Met1-Gln97
Accession # Q9UKS7
Specificity
Detects human Helios in direct ELISA.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IKZF2
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Helios Antibody (736440) [Alexa Fluor® 488]

  • Helios
  • IKAROS family zinc finger 2 (Helios)
  • Ikaros family zinc finger protein 2
  • IKZF2
  • MGC34330
  • subfamily 1A, 2 (Helios)
  • zinc finger DNA binding protein Helios
  • zinc finger protein Helios
  • ZNF1A2
  • ZNFN1A2

Background

Helios, also known as IKZF2, is a 70 kDa DNA-binding transcription regulator in the Ikaros family that contains four N-terminal C2H2-type zinc finger domains (aa 112-219) and two C-terminal zinc finger domains (aa 471-523). Helios is expressed in developing hematopoietic and epithelial tissues and in adult T cells and thymic-derived regulatory T cells (Treg). It forms homodimers and also heterodimers with other Ikaros family proteins Ikaros, Pegasus, Eos, and Aiolos. Alternate splicing of human Helios generates a short isoform that lacks three of the the N-terminal zinc finger domains. This isoform is overexpressed in T cell leukemias where it can still dimerize with Ikaros proteins but functions as a dominant negative regulator. Within aa 1-97, human and mouse Helios share 96% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Helios Antibody (IC73092G) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 IC73092U
Alexa Fluor 405 IC73092V
Alexa Fluor 488 IC73092G
Alexa Fluor 594 IC73092T
Alexa Fluor 647 IC73092R
Alexa Fluor 700 IC73092N
Alexa Fluor 750 IC73092S

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Bioinformatics Tool for Helios Antibody (IC73092G)

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Contact Information

Learn the difference between western blot and simple western

Product PDFs

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Bioinformatics

Gene Symbol IKZF2