Recombinant Human Growth Hormone R Protein

Product Discontinued

Recombinant Human Growth Hormone R Protein Summary

• Description: Recombinant bioactive protein containing 237 amino acids for Human Growth Hormone R
  
  

  Source:E. coli
  Amino Acid Sequence:(P10912)

• Details of Functionality: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH. 30.3 kDa (19-256 aa + N-terminal poly-his tag)
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: GHR
• Purity: >95%, by SDS-PAGE
• Endotoxin Note: <0.1 ng/ug

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Theoretical MW: 30.3 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.0045 mM sodium carbonate
• Concentration: Lyoph
• Purity: >95%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute in sterile dH2O to no less than 100 ug/ml. This solution can then be diluted into other aqueous buffers.

Alternate Names for Recombinant Human Growth Hormone R Protein

• GH receptor
• GHBP
• GHR
• growth hormone binding protein
• Growth Hormone R
• growth hormone receptor
• serum binding protein
• Somatotropin receptor

Background

GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: GHR