GRHL2 Antibody

Images

 
Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human skin shows strong nuclear positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human urinary bladder shows strong nuclear positivity in urothelial cells.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GRHL2 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: NRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQK
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRHL2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence -Reported in scientific literature (PMID:24375798)
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
Application Notes
Use in ICC/IF reported in scientific literature (PMID:24375798). For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
GRHL2 Protein (NBP1-88552PEP)
Publications
Read Publications using
NBP1-88552 in the following applications:

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (87%). Use in Mouse reported in scientific literature (PMID:24375798).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for GRHL2 Antibody

  • BOMMGC149294
  • Brother of mammalian grainyhead
  • deafness, autosomal dominant 28
  • DFNA28
  • FLJ13782
  • grainyhead-like 2 (Drosophila)
  • grainyhead-like protein 2 homolog
  • TFCP2L3MGC149295
  • Transcription factor CP2-like 3FLJ11172

Background

TFCP2L3 is a member of a family of transcription factor genes whose archetype is TFCP2 (MIM 189889), a mammalian ortholog of the Drosophila gene 'grainyhead' (grh).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GRHL2 Antibody (NBP1-88552)(7)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-P, WB.


Filter By Application
ICC/IF
(1)
IF/IHC
(3)
IHC-P
(1)
WB
(1)
All Applications
Filter By Species
Human
(3)
Mouse
(1)
All Species
Showing Publications 1 - 7 of 7.
Publications using NBP1-88552 Applications Species
Quan Y, Xu M et al. Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer. J Cancer 2015-03-15 [PMID: 25767604] (IF/IHC, WB, Human) IF/IHC, WB Human
Torres-Reyes LA, Alvarado-Ruiz L, Pina-Sanchez P et al. Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer. Int J Clin Exp Pathol 2014-01-01 [PMID: 25550776] (IF/IHC, Human) IF/IHC Human
Butz H, Szabo PM, Nofech-Mozes R et al. Integrative Bioinformatics Analysis Reveals New Prognostic Biomarkers of Clear Cell Renal Cell Carcinoma. Clin Chem. 2014-08-19 [PMID: 25139457] (IHC-P) IHC-P
Quan Y, Jin R, Huang A et al. Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1. Cancer Biol Ther 2014-07-01 [PMID: 24756066] (IF/IHC, Human) IF/IHC Human
Varma S, Mahavadi P et al. Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2014-01-03 [PMID: 24375798] (ICC/IF, Mouse) ICC/IF Mouse
Gao X, Vockley CM, Pauli F et al. Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium. Proc Natl Acad Sci U S A 2013-06-04 [PMID: 23690579]
Varma S, Cao Y, Tagne JB et al. The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation. J Biol Chem 2012-10-26 [PMID: 22955271]

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol GRHL2