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Granzyme B Antibody (GrB-7)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC
Clone
GrB-7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Granzyme B Antibody (GrB-7) Summary

Immunogen
The antibody reacts with the 33 kD human serine protease granzyme B.
Specificity
Does not react with human granzyme A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
GZMB
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
The monoclonal antibody stains granzyme B expressing lymphocytes in sections of sublimate formaldehyde as well as formalin fixed paraffin embedded tissues. It does not react with other cell types. The antibody can not be used on frozen sections. The antibBefore use in immunocytochemistry the slides have to be pretreated with 0.1 M sodium citrate, for 10 min. at 100 degrees C (in microwave oven). A working dilution of 1:20 is advised but optimal dilution should be tested by serial dilution.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Serum free tissue culture supernatant, 0.1% BSA
Preservative
0.09% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for Granzyme B Antibody (GrB-7)

  • C11
  • CCPI
  • CGL1
  • CGL-1
  • CSPB
  • CSP-B
  • CTLA1
  • CTLA-1
  • CTSGL1
  • Fragmentin-2
  • Granzyme B
  • Granzyme-2
  • GranzymeB
  • GRB
  • GrzB
  • GZMB
  • HLP
  • SECT

Background

Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Granzyme B
Antibody (GrB-7)
NBP1-51746
Granzyme B Antibody (GrB-7)
Species: Hu
Applications: ELISA, IHC

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GZMB