GPIHBP1 Antibody [FITC]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

GPIHBP1 Antibody [FITC] Summary

Immunogen
A synthetic peptide corresponding to an internal region [within residues 170-250] of mouse GPIHBP1. [Swiss-Prot# Q9D1N2]
Localization
Plasma membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GPIHBP1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This GPIHBP1 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot. A flash ECL exposure is recommended for first try. In ICC/IF membrane staining was observed.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for GPIHBP1 Antibody [FITC]

  • glycosylphosphatidylinositol anchored high density lipoprotein binding protein1
  • glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein1
  • GPI anchored high density lipoprotein binding protein 1
  • GPI-Anchored HDL-Binding Protein 1
  • GPIHBP1
  • GPI-HBP1
  • GPI-HBP1LOC338328
  • HBP1
  • High density lipoprotein-binding protein 1
  • HYPL1D

Background

GPIHBP1 (glycosylphosphatidylinositol-anchored HDL-binding protein 1) is a glycosylphosphatidylinositol-anchored glycoprotein of capillary endothelial cells that shuttle lipoprotein lipase (LPL) from the interstitial spaces to capillary lumen, and is essential for triglyceride-rich lipoproteins metabolism in mammalian plasma. GPIHBP1 is localized on luminal/abluminal capillary endothelial cell surfaces where it is bound by a glycosylphosphatidylinositol anchor and associates strongly with LPL. It serves as LPL transporter from sub-endothelial spaces to luminal face of capillaries, enabling lipolysis of circulating triglycerides localized within plasma chylomicrons. It has high affinity for HDL and binds to LPL, chylomicrons as well as APOA5. In the absence of GPIHBP1, the stores of catalytically active LPL within tissues are normal, but the LPL is mislocalized to interstitial spaces and is absent from capillary lumen. LPL mislocalization interferes with lipoprotein lipolysis and causes chylomicronemia. In humans, loss of function GPIHBP1 mutations leads to familial chylomicronemia. It binds LPL and apoA-V strongly for serving as a platform for lipolysis within capillaries, particularly in tissues which show high expression levels for both GPIHBP1 and LPL genes, such as heart, skeletal muscle and adipose tissue. Gpihbp1-/Gpihbp1- knock out mice have shown that GPIHBP1-deficiency causes severe hypertriglyceridemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GPIHBP1
Entrez