GPIHBP1 Antibody


Western Blot: GPIHBP1 Antibody [NB110-41537] - Detection of Gpibph1 in transfected lysate (lane 1) & empty vector lysate was used as a negative control (Lane 2).
Immunocytochemistry/ Immunofluorescence: GPIHBP1 Antibody [NB110-41537] - Gpihbp1 antibody was tested in A431 cells with FITC (green). Nuclei and alpha-tubulin were counterstained with Dapi (blue) and Dylight 550 (red).

Product Details

Reactivity Mu, Rt, BvSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
0.95 mg/ml

GPIHBP1 Antibody Summary

A synthetic peptide corresponding to an internal region [within residues 100-170] of mouse GPIHBP1. [Swiss-Prot# Q9D1N2]
Plasma membrane.
Immunogen affinity purified
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Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Tris-glycine, 150 mM NaCl
0.05% Sodium Azide
0.95 mg/ml
Immunogen affinity purified


Application Notes
This GPIHBP1 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot analysis. Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 24735886)
Control Peptide
GPIHBP1 Peptide (NB110-41537PEP)
Read Publications using
NB110-41537 in the following applications:

Reactivity Notes

Mouse. Rat and Bovine reactivity reported in scientific literature (PMID: 24735886)

Alternate Names for GPIHBP1 Antibody

  • glycosylphosphatidylinositol anchored high density lipoprotein binding protein1
  • glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein1
  • GPI anchored high density lipoprotein binding protein 1
  • GPI-anchored HDL-binding protein 1
  • GPI-HBP1LOC338328
  • HBP1
  • High density lipoprotein-binding protein 1


GPIHBP1 (glycosylphosphatidylinositol-anchored HDL-binding protein 1) is a glycosylphosphatidylinositol-anchored glycoprotein of capillary endothelial cells that shuttle lipoprotein lipase (LPL) from the interstitial spaces to capillary lumen, and is essential for triglyceride-rich lipoproteins metabolism in mammalian plasma. GPIHBP1 is localized on luminal/abluminal capillary endothelial cell surfaces where it is bound by a glycosylphosphatidylinositol anchor and associates strongly with LPL. It serves as LPL transporter from sub-endothelial spaces to luminal face of capillaries, enabling lipolysis of circulating triglycerides localized within plasma chylomicrons. It has high affinity for HDL and binds to LPL, chylomicrons as well as APOA5. In the absence of GPIHBP1, the stores of catalytically active LPL within tissues are normal, but the LPL is mislocalized to interstitial spaces and is absent from capillary lumen. LPL mislocalization interferes with lipoprotein lipolysis and causes chylomicronemia. In humans, loss of function GPIHBP1 mutations leads to familial chylomicronemia. It binds LPL and apoA-V strongly for serving as a platform for lipolysis within capillaries, particularly in tissues which show high expression levels for both GPIHBP1 and LPL genes, such as heart, skeletal muscle and adipose tissue. Gpihbp1-/Gpihbp1- knock out mice have shown that GPIHBP1-deficiency causes severe hypertriglyceridemia.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GPIHBP1 Antibody (NB110-41537)(5)

We have publications tested in 3 confirmed species: Mouse, Rat, Bovine.

We have publications tested in 3 applications: ICC/IF, IHC-P, WB.

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Product General Protocols

View specific protocols for GPIHBP1 Antibody (NB110-41537): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-41537AF405
Alexa Fluor (R) 488 Labeled NB110-41537AF488
Alexa Fluor (R) 647 Labeled NB110-41537AF647
Alexa Fluor (R) 700 Labeled NB110-41537AF700
Biotin Labeled NB110-41537B
DyLight 405 Labeled NB110-41537V
DyLight 488 Labeled NB110-41537G
DyLight 550 Labeled NB110-41537R
DyLight 650 Labeled NB110-41537C
FITC Labeled NB110-41537F
HRP Labeled NB110-41537H

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Contact Information

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Gene Symbol GPIHBP1

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