Glyoxalase I Antibody (Glo1a) [DyLight 405]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clone
Glo1a
Clonality
Monoclonal
Host
Mouse

Glyoxalase I Antibody (Glo1a) [DyLight 405] Summary

Immunogen
Full length human GLO1 protein [Swiss-Prot #Q04760].
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GLO1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 405
Format
DyLight 405 (A=400, E=420)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/ml
  • ELISA 0.15 ng / 1 ug protein
  • Immunocytochemistry/Immunofluorescence 10 ug/ml
Application Notes
This GLO1 antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~21 kDa. Immunoprecipitation was reported in scientific literature.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Glyoxalase I Antibody (Glo1a) [DyLight 405]

  • Aldoketomutase
  • EC 4.4.1.5
  • GLO1
  • GLOD1
  • Glx I
  • GLYI
  • glyoxalase domain containing 1
  • Glyoxalase I
  • glyoxalase Ialdoketomutase
  • Ketone-aldehyde mutase
  • lactoyl glutathione lyase
  • lactoylglutathione lyase
  • Methylglyoxalase
  • S-D-lactoylglutathione methylglyoxal lyase

Background

Glyoxalase 1 (GLO1) is the main enzyme in glyoxalase system, a metabolic pathway responsible for detoxifying alpha-oxoaldehydes, particularly methylglyoxal; and is known for converting reactive dicarbonyls into non-toxic intermediates ultimately protecting living cells from producing and accumulating advanced glycation end products, AGEs. GLO1 has also been studied with reference to anxiety, and a murine model showed that this gene's overexpression increases anxiety-related behavior by reducing the GABAA receptor agonist MG. Moreover, an association analysis in a human population with anxiety disorder subtypes suggested a role for GLO1's implication in this phenotype. GLO1 plays an important role in tumour growth and partly in chemotherapy survival as evidenced by a number of studies suggesting that some tumours rely on GLO1 to increase their viability and resistance to multiple chemotherapeutic agents. Furthermore, genetic studies have implicated GLO1 polymorphisms in panic disorder and restless legs syndrome (RLS).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Glyoxalase I Antibody (NBP1-19015V) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP1-19015APC
Biotin Labeled NBP1-19015B
DyLight 350 Labeled NBP1-19015UV
DyLight 405LS Labeled NBP1-19015V3
DyLight 488 Labeled NBP1-19015G
DyLight 550 Labeled NBP1-19015R
DyLight 650 Labeled NBP1-19015C
DyLight 680 Labeled NBP1-19015FR
DyLight 755 Labeled NBP1-19015IR
FITC Labeled NBP1-19015F
HRP Labeled NBP1-19015H
PE Labeled NBP1-19015PE
PerCP Labeled NBP1-19015PCP

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Blogs on Glyoxalase I

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol GLO1
Entrez
Uniprot

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