Glutaminyl-peptide Cyclotransferase/QPCT Antibody

Product Discontinued

Glutaminyl-peptide Cyclotransferase/QPCT Antibody Summary

• Immunogen: QPCT (NP_036545, 262 a.a. ~ 360 a.a) partial recombinant protein with GST tag.PNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYL
• Specificity: glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: QPCT
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: The quality control of this antibody is limited to Western blot on the immunizing protein. It has also been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Glutaminyl-peptide Cyclotransferase/QPCT Antibody

• EC 2.3.2.5
• GCT
• Glutaminyl cyclase
• glutaminyl-peptide cyclotransferase
• Glutaminyl-tRNA cyclotransferase
• Glutamyl cyclase
• QCEC
• QPCT
• sQC

Background

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Glutaminyl-peptide Cyclotransferase/QPCT Antibody (H00025797-A01)(4)

Publications using H00025797-A01

• Morawski M, Schilling S, Kreuzberger M et al. Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-? Load and Cognitive Decline in Alzheimers Disease. J Alzheimers Dis 2013-10-28 [PMID: 24164736]
• Chen YL, Huang KF, Kuo WC et al. Inhibition of Glutaminyl Cyclase Attenuates Cell Migration Modulated by Monocyte Chemoattractant Proteins. Biochem J. 2011-11-08 [PMID: 22060158]
• Hartlage-Rubsamen M, Morawski M, Waniek A et al. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A?] deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol. 2011-02-08 [PMID: 21301857]
• Morawski M, Hartlage-Rubsamen M, Jager C et al. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathol. 2010-04-10 [PMID: 20383514]

Bioinformatics

• Gene Symbol: QPCT
• Entrez:
  • 25797(Human)
• OMIM:
  • 607065(Human)
• Uniprot:
  • NP_036545(Human)