Glutamate Receptor 3 Antibody (1D2)

Western Blot: Glutamate Receptor 3 Antibody (1D2) [NBP2-37584] - Western blot analysis using GRIA3 mAb against HEK293 (1) and GRIA3(AA: 683-824)-hIgGFc transfected HEK293 (2) cell lysate.

Immunohistochemistry-Paraffin: Glutamate Receptor 3 Antibody (1D2) [NBP2-37584] - Immunohistochemical analysis of paraffin-embedded human brain tissues (left) and rat brain tissues (right) using GRIA3 mouse mAb with DAB staining.

ELISA: Glutamate Receptor 3 Antibody (1D2) [NBP2-37584] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);

Product Discontinued

Glutamate Receptor 3 Antibody (1D2) Summary

• Immunogen: Purified recombinant fragment of human GRIA3 expressed in E. Coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GRIA3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Immunohistochemistry 1:200 - 1:1000
  • Immunohistochemistry-Paraffin 1:200-1:1000
  • Western Blot 1:500 - 1:2000
• Theoretical MW: 101 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.03% Sodium Azide
• Purity: Unpurified

Alternate Names for Glutamate Receptor 3 Antibody (1D2)

• AMPA 3
• AMPA3
• AMPA-selective glutamate receptor 3
• GluA3
• GluR3
• GluR-3
• GLURC
• GLUR-C
• GLUR-K3
• glutamate receptor C
• glutamate receptor subunit 3
• glutamate receptor, ionotrophic, AMPA 3
• GRIA3

Background

The GRIA3 gene encodes for glutamate receptor 3 with an isoform flop and flip of 894 amino acids, 101 kDA each. Glutamate receptors function as a ligand-gated ion channel in the central nervous system and are the predominant excitatory neurotransmitter receptors in the brain. GRIA3 is involved in glutamic acid signaling, calcium channels, CREB pathways, pathogenesis of ALS, and glutamatergic synapses. It is known to interact with GRIA2, DLG4, NSF, SQSTM1, and SDCBP. GRIA3 has been researched with various diseases such as bipolar disorder, encephalitis, mood disorder, rett syndrome, lateral sclerosis, auditory neuropathy, epilepsy, smith-fineman-myers syndrome, and nonsyndromic deafness, and canavan disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRIA3