Glucagon R/GCGR Antibody (volagidemab) [Allophycocyanin]

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clone: volagidemab
• Clonality: Monoclonal
• Host: Human
• Conjugate: Allophycocyanin

Glucagon R/GCGR Antibody (volagidemab) [Allophycocyanin] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: GCGR
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Human
• Gene: GCGR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Alternate Names for Glucagon R/GCGR Antibody (volagidemab) [Allophycocyanin]

• FLJ97182
• GCGR
• GGR
• GLR
• GL-R
• Glucagon R
• glucagon receptor
• GlucagonR
• MGC138246

Background

Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GCGR