GIPR Antibody (591853) [Alexa Fluor™ Plus 488]

• Clone: 591853
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

GIPR Antibody (591853) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human GIPR in direct ELISAs. Stains human GIPR transfected cells but not irrelevant transfectants.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GIPR Antibody (591853) [Alexa Fluor™ Plus 488]

• gastric inhibitory polypeptide receptor
• GIPR
• GIP-R
• Glucose-dependent insulinotropic polypeptide receptor
• MGC126722
• PGQTL2

Background

GIPR is a 7-transmembrane receptor for GIP (glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide). The 466 amino acid (aa) human GIPR contains 176 extracellular domain (ECD) aa that share 77% and 81% aa identity with mouse and rat GIPR ECD, respectively. A splice isoform of 430 aa has a deletion of aa 58-93 in the N-terminal ECD, while isoforms of 491 and 419 aa have alternate C-terminal cytoplasmic sequences. Engagement by GIP on pancreatic b‑cells activates adenylate cyclase to regulate insulin compensation in the presence of high circulating glucose. GIPR is also expressed on adipocytes, osteoblasts and myelinating Schwann cell membranes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.