GIPR Antibody (12C6) - BSA Free

ELISA: GIPR Antibody (12C6) [NBP3-26553] - The Binding Activity of Rat GIPR with GIPR Antibody.Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat GIPR at 2 ug/mL can bind GIPR Antibody, the EC50 is 6.946-8.740 ng/mL.

ELISA: GIPR Antibody (12C6) [NBP3-26553] - The Binding Activity of Mouse GIPR with GIPR Antibody. Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse GIPR at 2 ug/mL can bind GIPR Antibody, the EC50 is 8.622-11.36 ng/mL.

• Reactivity: Mu, Rt
• Applications: ELISA
• Clone: 12C6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

GIPR Antibody (12C6) - BSA Free Summary

• Description: Novus Biologicals Mouse GIPR Antibody (12C6) - BSA Free (NBP3-26553) is a recombinant monoclonal antibody validated for use in ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant monoclonal antibody expressed in HEK293F cells
• Immunogen: Recombinant Human GIPR protein [UniProt Q0P543]
• Source: HEK293
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: GIPR
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol, 0.01M PBS, PH 7.4
• Preservative: 0.03% Proclin 300
• Purity: Affinity purified

Alternate Names for GIPR Antibody (12C6) - BSA Free

• gastric inhibitory polypeptide receptor
• GIPR
• GIP-R
• Glucose-dependent insulinotropic polypeptide receptor
• MGC126722
• PGQTL2

Background

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GIPR