Recombinant Human GilZ His Protein

SDS-Page: GilZ Protein [NBP2-22895]

• Reactivity: Hu
• Applications: PAGE
• Concentration: 1 mg/ml

Recombinant Human GilZ His Protein Summary

• Description: A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-134 of Human GilZ
  
  

  Source: E.coli

  Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: TSC22D3
• Purity: >85%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 17.2 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 10% glycerol, 1 mM DTT
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: >85%, by SDS-PAGE

Alternate Names for Recombinant Human GilZ His Protein

• Delta sleep-inducing peptide immunoreactor
• DSIP-immunoreactive leucine zipper protein
• DSIP-immunoreactive peptide
• GILZDKFZp313A1123
• Glucocorticoid-induced leucine zipper protein
• Protein DIP
• TSC22 domain family protein 3
• TSC22 domain family, member 3
• TSC-22 related protein
• TSC-22-like protein
• TSC-22-related protein
• TSC-22Rimmunoreactor

Background

TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: TSC22D3