Recombinant Human GDF-15 Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func, PAGE, Bioactivity
Concentration
LYOPH

Order Details

Recombinant Human GDF-15 Protein Summary

Description
Mature human recombiinant GDF-15 protein: aminoacids Ala197-Ile308 with an N-terminal 6-His tag. A biologically active protein GDF15.Source: E. coli
Preparation
Method
Novus' biologically active proteins are stringently purified to provide only the safest and most highly effective proteins available. This protein was expressed CHO cells, purified by HPLC, QC tested by SDS-PAGE and Western Blot and validated on appropriate cell lines for bioactivity. All HPLC and bioactivity data is provided for your assurance.
Details of Functionality
Data is not available.
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
GDF15
Endotoxin Note
Less than 1 EU/ug of the rHuGDF-15 as determined by LAL method.

Applications/Dilutions

Theoretical MW
13 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration
LYOPH
Reconstitution Instructions
Reconstitute with sterilized 4 mM HCl to a final concentration of 0.1 mg/ml. Stock solutions should be apportioned into working aliquots and stored at -20C. Further dilutions should be made in appropriately buffered solutions.

Notes

This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.

Alternate Names for Recombinant Human GDF-15 Protein

  • GDF15
  • GDF-15
  • growth differentiation factor 15
  • growth/differentiation factor 15
  • Macrophage inhibitory cytokine 1
  • MIC-1
  • MIC-1NSAID-activated gene 1 protein
  • MIC1Prostate differentiation factor
  • NAG-1
  • NAG-1NSAID-regulated gene 1 protein
  • NSAID (nonsteroidal inflammatory drug)-activated protein 1
  • PDF
  • PDFGDF-15
  • PLAB
  • PLABNRG-1
  • Placental bone morphogenetic protein
  • Placental TGF-beta
  • PTGF-beta
  • PTGFBPTGF-beta

Background

Growth Differentiation Factor 15 (GDF-15) is a divergent member of the TGF-beta superfamily. Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein. Human GDF-15 shares 67% aa sequence identity with rat and mouse GDF-15. GDF-15 is expressed in placenta, brain, kidney, pancreas, prostate, and colon. It inhibits macrophage and platelet activation, regulates angiogenesis, and promotes recovery following myocardial infarction. GDF-15 also promotes cartilage formation, neuronal survival, and appetite suppression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol GDF15