Gastrokine 1 Antibody (665701) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 665701
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Gastrokine 1 Antibody (665701) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Gastrokine 1
  Asn35-Asn199
  Accession # Q9NS71
• Specificity: Detects human Gastrokine 1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse Gastrokine 1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Gastrokine 1 Antibody (665701) [Alexa Fluor® 488]

• 18 kDa antrum mucosa protein
• AMP18
• AMP-18
• AMP18BRICHOS domain containing 1
• BRICD1
• CA11
• CA11MGC70354
• FOV
• Foveolin
• Gastrokine 1
• gastrokine-1
• GKN1
• Protein CA11

Background

Gastrokine 1 (GKN1; also CA11 and AMP-18) is an 18 kDa member of the CA11 protein family. It has limited expression, being restricted to mucous secreting pyloric atrial epithelium. Gastrokine 1 appears to promote epithelial proliferation and migration, and induce the formation of tight junctions between epithelial cells. Mature human Gastrokine 1 is 165 amino acids (aa) in length. Based on the SwissProt sequence, it possesses one BRICHOS domain (aa 54-150) that contains a mitogenic sequence (aa 97-117). There is one potential alternative start site 14 aa upstream of the standard site that does not appear to be utilized. Over aa 21-185 (aa 35-199 of SwissProt), human Gastrokine 1 shares 65% aa identity with mouse Gastrokine 1.  

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.