GABA-AR alpha 4 Antibody (S398A-34) [DyLight 405]

• Reactivity: Hu, Mu, Rt
• Applications: ICC/IF, IHC
• Clone: S398A-34
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 405

GABA-AR alpha 4 Antibody (S398A-34) [DyLight 405] Summary

• Immunogen: Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4
• Localization: Cell Junction , Synapse , Postsynaptic Cell Membrane , Cell Membrane
• Specificity: Detects 60kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GABRA4
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for GABA-AR alpha 4 Antibody (S398A-34) [DyLight 405]

• GABA A R alpha 4
• GABA(A) receptor subunit alpha-4
• GABAAR alpha 4
• GABAARa4
• GABRA4
• gamma-aminobutyric acid (GABA) A receptor, alpha 4
• gamma-aminobutyric acid receptor subunit alpha-4

Background

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GABA-AR alpha 4 Antibody (NBP2-59326V)(1)

Publication using NBP2-59326V

• Wang G, Peng S, Reyes Mendez M et al. The TMEM132B-GABA A receptor complex controls alcohol actions in the brain. Cell 2024-09-27 [PMID: 39357522]

Bioinformatics

• Gene Symbol: GABRA4