GABA-AR alpha 3 Antibody - BSA Free

Western Blot: GABA-AR alpha 3 Antibody - BSA Free [NBP3-46279] - Human brain tissue were subjected to SDS PAGE followed by western blot with (GABA-AR alpha 3 antibody) at dilution of 1:100

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

GABA-AR alpha 3 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit GABA-AR alpha 3 Antibody - BSA Free (NBP3-46279) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: gamma-aminobutyric acid(GABA) A receptor, alpha 3. (Uniprot# P34903)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GABRA3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500-1:2000
• Theoretical MW: 55 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for GABA-AR alpha 3 Antibody - BSA Free

• GABA A R alpha 3
• GABA(A) receptor subunit alpha-3
• GABAARa3
• GABRA3
• gamma-aminobutyric acid (GABA) A receptor, alpha 3
• gamma-aminobutyric acid receptor subunit alpha-3
• gamma-animobutyric acid (GABA) A receptor, alpha 3
• MGC33793

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GABRA3