GABA-A R beta 2 Antibody

Product Discontinued

GABA-A R beta 2 Antibody Summary

• Immunogen: Peptide with sequence C-HSFGRNALERHVAQ corresponding to internal region according to NP_000804.1.
• Epitope: internal region
• Specificity: This antibody is expected to recognize both reported isoforms (NP_068711.1; NP_000804.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: GABRB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:4000
• Application Notes: WB: Preliminary experiments gave an approx. 80 kDa band in mouse brain lysates after 0.2 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 59.2 kDa band according to human NP_068711.1 and 54.6 kDa band according to mouse NP_032096.1. The 80 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for GABA-A R beta 2 Antibody

• GABA A R beta 2
• GABA(A) receptor subunit beta-2
• GABAAR beta 2
• GABAARb2
• GABRB2
• gamma-aminobutyric acid (GABA) A receptor, beta 2
• gamma-aminobutyric acid A receptor beta 2
• gamma-aminobutyric acid receptor subunit beta-2
• MGC119386
• MGC119388
• MGC119389

Background

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GABA-A R beta 2 Antibody (NBP1-36958)(1)

Publication using NBP1-36958

• Lo WS, Lau CF, Xuan Z et al. Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia. Mol Cell 2004-06-01 [PMID: 14699426]

Bioinformatics

• Gene Symbol: GABRB2
• Entrez:
  • 2561(Human)
  • 14401(Mouse)
  • 25451(Rat)
• Uniprot:
  • NP_068711.1(Human)