FSH beta Antibody (961416) [Unconjugated]

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Western blot shows lysates of human pituitary gland tissue. PVDF membrane was probed with 2 µg/mL of Rat Anti-Human FSH beta Monoclonal Antibody (Catalog # MAB43101) followed by HRP-conjugated Anti-Rat ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
961416
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

FSH beta Antibody (961416) [Unconjugated] Summary

Immunogen
E.coli-derived recombinant human FSH beta
Asn19-Glu129
Accession # P01225
Specificity
Detects human FSH beta in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FSH beta Antibody (961416) [Unconjugated]

  • follicle stimulating hormone, beta polypeptide
  • Follicle-stimulating hormone beta subunit
  • Follitropin beta chain
  • follitropin subunit beta
  • Follitropin
  • follitropin, beta chain
  • FSH beta
  • FSHB
  • FSH-B
  • FSH-beta

Background

Follicle-stimulating hormone (FSH; also follitropin) is a 33 kDa heterodimer belonging to the glycoprotein hormones subunit beta family (1). The heterodimer is composed of two glycoproteins linked noncovalently: a common alpha subunit, which is also a component of luteinizing hormone, thyroid stimulating hormone, and chorionic gonadotropin; and a unique beta subunit that confers the protein’s specific biological action and is responsible for the interaction with FSH-receptor. The alpha subunit is 20 kDa and is synthesized as a 116 amino acid (aa) precursor that contains a 24 aa signal sequence and a 92 aa mature chain, which contains two potential sites of N-linked glycosylation (1-2). The beta subunit is 23 kDa and is synthesized as a 129 aa precursor with an 18 aa signal sequence and a 111 aa mature chain, which also contains two potential sites of N-linked glycosylation (1). Human FSH beta shares approximately 90% aa sequence identity with mouse and rat FSH beta. FSH is secreted by gonadotropes of the anterior pituitary gland.  Its release is controlled by pulses of gonadotropin-releasing hormone (GnRH), and those pulses, in turn, are subject to the estrogen feedback from the gonads. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the human body. It promotes follicle maturation and spermatogenesis through interactions with FSH-receptor.
  1. Van de Wiel, D.F. et al. (1998) J. Mol. Endocrinol. 20:83.
  2. Rathnam, P. and B.B. Saxena (1975) J. Biol. Chem. 250:6735.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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