Frizzled-8 Antibody

Immunohistochemistry-Paraffin: Frizzled-8 Antibody [NLS4776] - Anti-FZD8 / Frizzled 8 antibody IHC of human brain, substantia nigra. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: Frizzled-8 Antibody [NLS4776] - IHC analysis of Pancreas, Islet of Langerhan's using this antibody at 7 ug/ ml.

Immunohistochemistry-Paraffin: Frizzled-8 Antibody [NLS4776] - Analysis of anti-FZD8 / Frizzled 8 antibody with human brain, amygdala.

Immunohistochemistry-Paraffin: Frizzled-8 Antibody [NLS4776] - Anti-FZD8 / Frizzled 8 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: Frizzled-8 Antibody [NLS4776] - Anti-FZD8 / Frizzled 8 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

Frizzled-8 Antibody Summary

• Immunogen: Synthetic 12 amino acid peptide from N-terminal extracellular domain of human FZD8 / Frizzled 8.
• Specificity: Human FZD8 / Frizzled 8. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Opossum (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FZD8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 7 - 17 ug/ml

Reactivity Notes

Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Lizard (83%), Seabass (83%), Pufferfish (83%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Frizzled-8 Antibody

• frizzled (Drosophila) homolog 8
• frizzled 8
• frizzled family receptor 8
• frizzled homolog 8 (Drosophila)
• Frizzled8
• Frizzled-8
• FZ-8
• FZD8
• hFZ8

Background

Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FZD8
• Entrez:
  • 8325(Human)