Hu, Mu, Rt, Bv, CaApplications:
WB, ICC/IF, IHC, IHC-P, PEP-ELISAHost:
Applications: WB, IHC
Host: Goat Polyclonal
Host: Rat Monoclonal
Binding Activity, Bioactivity
"Frizzled-8 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
|Product By Gene ID
- frizzled (Drosophila) homolog 8
- frizzled 8
- frizzled family receptor 8
- frizzled homolog 8 (Drosophila)
Bioinformatics Tool for Frizzled-8
Discover related pathways, diseases and genes to Frizzled-8. Need help? Read the Bioinformatics Tool Guide
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