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"Frizzled-8 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
![Binding Activity Frizzled-8 [Biotin]](http://images.novusbio.com/fullsize/protein/Frizzled8_BT6129_2539.jpg)
![SDS-Page Frizzled-8 [Biotin]](http://images.novusbio.com/fullsize/protein/Frizzled8_BT6129_2452.jpg)