Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, ELISA, ICC/IF, IHC
Host: Goat Polyclonal
Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt, Bv, Ca, Pm, Rb, Pm
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: Binding Activity, Bioactivity
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Description
"Frizzled-8 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Mouse
Human
|
| Product By Gene ID |
8325 |
| Alternate Names |
- frizzled (Drosophila) homolog 8
- frizzled 8
- frizzled family receptor 8
- frizzled homolog 8 (Drosophila)
- frizzled-8
- Fz-8
- FZ-8
- hFZ8
- hFz8
|
![Binding Activity Frizzled-8 [Biotin]](http://images.novusbio.com/fullsize2/Frizzled8_BT6129_2539.jpg)
![SDS-PAGE Frizzled-8 [Biotin]](http://images.novusbio.com/fullsize2/Frizzled8_BT6129_2452.jpg)