FPR1 Antibody - BSA Free

Immunohistochemistry-Paraffin: FPR1 Antibody [NLS2086] - Analysis of anti-FPR1 antibody with human tonsil.

• Reactivity: Hu, Pm, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

FPR1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from 2nd extracellular domain of human FPR1.
• Epitope: 2nd extracellular domain
• Localization: Cell Membrane
• Specificity: Human FPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (94%), Chimpanzee (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FPR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (94%), Orangutan (88%), Gibbon (81%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FPR1 Antibody - BSA Free

• fMet-Leu-Phe receptor
• fMLF-R
• fMLP receptor
• FMLP
• formyl peptide receptor 1
• FPR1
• FPRfMet-Leu-Phe receptor
• N-formyl peptide receptor
• N-formylpeptide chemoattractant receptor

Background

Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection. (WO0157074) FPR1 has been reported in blood monocytes, neutrophils, and phagocytes, as well as in liver, astrocytes, and microglia. ESTs have been isolated from B-cell/lung/testis, blood, brain, eye, heart, liver/spleen, kidney, lung, pancreas, placenta, spleen, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FPR1 Antibody (NLS2086)(1)

Publication using NLS2086

• Minopoli M, Botti G, Gigantino V et al. Targeting the Formyl Peptide Receptor type 1 to prevent the adhesion of ovarian cancer cells onto mesothelium and subsequent invasion J. Exp. Clin. Cancer Res. 2019-11-08 [PMID: 31703596] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: FPR1
• Entrez:
  • 2357(Human)