FPR1 Products

Description

Official Gene Symbol: FPR1 Gen Bank Accession Number: NP_002020 Gene ID: 2357 (Human) Gene Map Locus: 19q13.4 (Human) FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeletion, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates.

Bioinformatics

Entrez	2357 Human
Uniprot	NP_002020 Human NP_002020.1 Human
Product By Gene ID	2357
Alternate Names	fMet-Leu-Phe receptor fMLP receptor FMLP formyl peptide receptor 1 FPRfMet-Leu-Phe receptor N-formyl peptide receptor N-formylpeptide chemoattractant receptor

Research Areas for FPR1

Find related products by research area and learn more about each of the different research areas below.

GPCR
Immunology
Protein Kinase