FoxP2 Antibody

Western Blot: FoxP2 Antibody [NBP1-51907] - Staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Antibody at 2 ug/mL. Detected by chemiluminescence. Approx 80-90 kDa band observe (calculated MW of 82.6 kDa according to NP_683696.2).

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

FoxP2 Antibody Summary

• Immunogen: Peptide with sequence C-REIEEEPLSEDLE corresponding to C-Terminus according to NP_055306.1, NP_683696.2, NP_683697.1.
• Epitope: C-REIEEEPLSEDLE
• Specificity: This antibody is expected to recognise all three reported isoforms (NP_055306.1; NP_683696.2; NP_683697.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FOXP2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:128000
  • Western Blot 0.5 - 2 ug/mL

Reactivity Notes

Expected from sequence similarity: Mouse, Rat, Canine, Porcine, Bovine

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FoxP2 Antibody

• CAG repeat protein 44
• CAGH44
• CAGH44TNRC10forkhead box protein P2
• DKFZp686H1726
• forkhead box P2
• forkhead/winged-helix transcription factor
• FoxP2
• SPCH1
• TNRC10
• trinucleotide repeat containing 10
• Trinucleotide repeat-containing gene 10 protein

Background

This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Multiple alternative transcripts encoding different isoforms have been identified. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FoxP2 Antibody (NBP1-51907)(1)

Publication using NBP1-51907

• Lai CS, Fisher SE, Hurst JA et al. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001-10-04 [PMID: 11586359]

Bioinformatics

• Gene Symbol: FOXP2
• Entrez:
  • 93986(Human)
• Uniprot:
  • NP_055306.1(Human)