FoxP1 Antibody (JC12)

Images

 
Western Blot: FOXP1 Antibody (JC12) [NB100-65125] - Western blot analysis of resonicated MCF7 cell lysate (A) and MCF7 cell lysate (B) using FOXP1 antibody at 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: FOXP1 Antibody (JC12) [NB100-65125] - FOXP1 antibody was tested at 1:25 in MCF-7 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and ...read more
Immunohistochemistry-Paraffin: FOXP1 Antibody (JC12) [NB100-65125] - IHC analysis of formalin-fixed paraffin-embedded tissue section of malignant stromal tumor of the human small bowel using mouse monoclonal FOXP1 ...read more
Flow Cytometry: FOXP1 Antibody (JC12) [NB100-65125] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HeLa (B) cells using FOXP1 antibody (dark blue). Isotype control shown in orange. An antibody ...read more
Immunohistochemistry-Paraffin: FOXP1 Antibody (JC12) [NB100-65125] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal breast using FOXP1 antibody (clone JC12) at 5 ug/ml concentration. The ...read more
Immunohistochemistry-Paraffin: FOXP1 Antibody (JC12) [NB100-65125] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal brain using mouse monoclonal FOXP1 antibody (clone JC12) at 5 ug/ml ...read more
Immunohistochemistry-Paraffin: FOXP1 Antibody (JC12) [NB100-65125] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal colon using mouse monoclonal FOXP1 antibody (clone JC12) at 5 ug/ml ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready
Clone
JC12
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

FoxP1 Antibody (JC12) Summary

Immunogen
Human FOXP1 [Uniprot# Q9H334]
Epitope
Within the C-terminus
Localization
Nuclear, Cytoplasmic
Specificity
Does not recognize closely related molecules FOXP2, FOXP3 or FOXP4.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
FOXP1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 1 ug per million cells
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:200-1:500
  • Immunoprecipitation
  • Western Blot 2ug/ml
Application Notes
Heat induced antigen retrieval with Sodium Citrate buffer pH 6.0 is recommended when using this antibody for IHC-P. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 15161711). Use in immunoprecipitation reported in scientific literature (PMID 17586580). This antibody is CyTOF ready.
Control
FoxP1 Overexpression Lysate
Publications
Read Publications using
NB100-65125 in the following applications:

  • 1 publication
  • IHC
    4 publications
  • 1 publication
  • IP
    1 publication
  • WB
    2 publications

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for FoxP1 Antibody (JC12)

  • FLJ23741
  • fork head-related protein like B
  • forkhead box P1
  • forkhead box protein P1
  • FoxP1
  • glutamine-rich factor 1
  • hFKH1B
  • HSPC215
  • MGC12942
  • MGC88572
  • MGC99551
  • QRF1
  • QRF112CC4

Background

FOXP1 is a member of the Forkhead Box Protein family. These proteins are transcription factors that are characterised by a highly conserved forkhead DNA-binding domain. FOXP1 is a repressor of transcription. It forms homodimers, and also heterodimerises with FOXP2 and FOXP4, to facilitate its binding to DNA for transcriptional regulation. A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukaemia, and FOXP1 is also implicated in mental retardation with language impairment and autistic features (MRLIAF). Chromosomal translocation of FOXP1 is implicated in mucosa-associated lymphoid tissue (MALT) lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for FoxP1 Antibody (NB100-65125)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: ICC/IF, IHC, IHC-P, IP, WB.


Filter By Application
ICC/IF
(1)
IHC
(4)
IHC-P
(1)
IP
(1)
WB
(2)
All Applications
Filter By Species
Human
(6)
All Species
Showing Publications 1 - 8 of 8.
Publications using NB100-65125 Applications Species
Gars E, Butzmann A, Ohgami R et al. The life and death of the germinal center Ann Diagn Pathol Nov 13 2019 [PMID: 31751845] (IHC, Human) IHC Human
Xie Y, Bulbul MA, Ji L et al. p53 Expression Is a Strong Marker of Inferior Survival in De Novo Diffuse Large B-Cell Lymphoma and May Have Enhanced Negative Effect With MYC Coexpression: A Single Institutional Clinicopathologic Study. Am. J. Clin. Pathol. 4/1/2014 [PMID: 24619762] (IHC-P, Human) IHC-P Human
Brown PJ, Ashe SL, Leich E et al. Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. Blood. 2008 Mar 1 [PMID: 18077790] (IHC, WB, Human) IHC, WB Human
Li B, Samanta A, Song X et al. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol. 2007 Jul [PMID: 17586580] (IP, Human) IP Human
Loddenkemper C, Maul J, Berg E et al. Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level. Eur J Immunol. 2006 Jan [PMID: 16380960] (IHC, Human) IHC Human
Banham, AH et al. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res11:1065 - 1072. 2005 [PMID: 15709173]
Fox SB, Brown P, Han C et al. Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. Clin Cancer Res. 2004 May 15 [PMID: 15161711] (IHC, ICC/IF, WB, Human) IHC, ICC/IF, WB Human
Banham, AH et al. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res 61:8820 - 8829. 2001 [PMID: 11751404]

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for FoxP1 Antibody (NB100-65125) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB100-65125AF350
Alexa Fluor 405 NB100-65125AF405
Alexa Fluor 488 NB100-65125AF488
Alexa Fluor 532 NB100-65125AF532
Alexa Fluor 594 NB100-65125AF594
Alexa Fluor 647 NB100-65125AF647
Alexa Fluor 700 NB100-65125AF700
Alexa Fluor 750 NB100-65125AF750
Allophycocyanin NB100-65125APC
Biotin NB100-65125B
DyLight 350 NB100-65125UV
DyLight 405 NB100-65125V
DyLight 488 NB100-65125G
DyLight 550 NB100-65125R
DyLight 594 NB100-65125DL594
DyLight 650 NB100-65125C
DyLight 680 NB100-65125FR
DyLight 755 NB100-65125IR
FITC NB100-65125F
HRP NB100-65125H
Janelia Fluor 549 NB100-65125JF549
Janelia Fluor 646 NB100-65125JF646
PE NB100-65125PE
PerCP NB100-65125PCP

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Bioinformatics

Gene Symbol FOXP1
Entrez
Uniprot