FOXL1 Antibody (1C3) - Azide and BSA Free

Immunohistochemistry-Paraffin: FOXL1 Antibody (1C3) [H00002300-M04] - Analysis of monoclonal antibody to FOXL1 on formalin-fixed paraffin-embedded human lung. Antibody concentration 3 ug/ml

• Reactivity: Hu
• Applications: WB, ELISA, IHC
• Clone: 1C3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

FOXL1 Antibody (1C3) - Azide and BSA Free Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: FOXL1 (NP_005241, 132 a.a. ~ 240 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MFENGNYRRRKRKPKPGPGAPEAKRPRAETHQRSAEAQPEAGSGAGGSGPAISRLQAAPAGPSPLLDGPSPPAPLHWPGTASPNEDAGDAAQGAAAVAVGQAARTGDGP
• Specificity: FOXL1 (1C3)
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: FOXL1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 1:500
• Application Notes: Antibody reactivity against recombinant protein with GST tag on ELISA and WB. It has been used for IHC-P.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for FOXL1 Antibody (1C3) - Azide and BSA Free

• FKH6forkhead box protein L1
• FKHL11forkhead-like 11
• forkhead box L1
• Forkhead-related protein FKHL11
• Forkhead-related transcription factor 7
• FREAC7FREAC-7

Background

FOXL1 is a 337 amino acid protein encoded by the mouse gene Foxl1. FOXL1 belongs to the fork head family and contains one fork head DNA-binding domain. The HNF3/fork head family includes a large number of transcription factors that share a structurally related DNA binding domain. Fork head factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1- deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyer's patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the adenomatous polyposis coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FOXL1 Antibody (H00002300-M04)(1)

Publication using H00002300-M04

• Yang FQ, Yang FP, Li W et al. Foxl1 inhibits tumor invasion and predicts outcome in human renal cancer. Int J Clin Exp Pathol. 2013-12-15 [PMID: 24427331]

Bioinformatics

• Gene Symbol: FOXL1
• Entrez:
  • 2300(Human)
• OMIM:
  • 603252(Human)
• Uniprot:
  • NP_005241(Human)