FLIP Antibody (896537) [Janelia Fluor® 525]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: 896537
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 525

FLIP Antibody (896537) [Janelia Fluor® 525] Summary

• Immunogen: E. coli-derived recombinant human FLIP
  Met1-Asn200
  Accession # O15519
• Specificity: Detects human FLIP in direct ELISAs and human, mouse, and rat FLIP in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CFLAR
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for FLIP Antibody (896537) [Janelia Fluor® 525]

• CASHFADD-like antiapoptotic molecule 1
• CASP8 and FADD-like apoptosis regulator
• CASP8AP1
• Caspase homolog
• Caspase-eight-related protein
• Caspase-like apoptosis regulatory protein
• caspase-related inducer of apoptosis
• CASPER
• CasperFLAME1
• Cellular FLICE-like inhibitory protein
• CFLAR
• c-FLIPR
• c-FLIPS
• CLARPMACH-related inducer of toxicity
• FADD-like apoptotic molecule
• FLAME
• FLAME-1
• FLIP
• I-FLICE
• I-FLICEMRITc-FLIPFLIPc-FLIPL
• Inhibitor of FLICE
• usurpin beta
• Usurpin

Background

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CFLAR