FIG4 Antibody

Product Discontinued

FIG4 Antibody Summary

• Immunogen: N Terminus Region of the target protein.
• Specificity: This product is specific for Human SAC3.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FIG4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20 mM Potassium Phosphate (pH 7.0), 0.15 M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for FIG4 Antibody

• ALS11polyphosphoinositide phosphatase
• CMT4J
• dJ249I4.1
• EC 3.1.3
• EC 3.1.3.-
• EC 3.1.3.36
• FIG4 homolog (S. cerevisiae)
• FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
• hSac3
• KIAA0274FIG4 homolog, SAC domain containing lipid phosphatase
• Phosphatidylinositol 3,5-bisphosphate 5-phosphatase
• Sac domain-containing inositol phosphatase 3
• SAC domain-containing protein 3
• SAC3FIG4 homolog, SAC1 domain containing lipid phosphatase

Background

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FIG4 Antibody (26160002)(3)

Publications using 26160002

• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Kon T, Mori F, Tanji K et al. ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases. Neuropathology 2013-07-29 [PMID: 23888880] (IHC-P, Human)
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Bioinformatics

• Gene Symbol: FIG4
• Uniprot:
  • Q92562(Human)