FIG4 Products

Description

The protein encoded by the FIG4 gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. (provided by RefSeq)

Bioinformatics

Entrez	9896 Human
Uniprot	NM_014845 Human NP_055660.1 Human Q92562 Human
Product By Gene ID	9896
Alternate Names	ALS11polyphosphoinositide phosphatase CMT4J dJ249I4.1 EC 3.1.3 EC 3.1.3.- EC 3.1.3.36 FIG4 homolog (S. cerevisiae) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) hSac3 KIAA0274FIG4 homolog, SAC domain containing lipid phosphatase Phosphatidylinositol 3,5-bisphosphate 5-phosphatase Sac domain-containing inositol phosphatase 3 SAC domain-containing protein 3 SAC3FIG4 homolog, SAC1 domain containing lipid phosphatase