Fibulin 5/DANCE Antibody (3F8D5)

Western Blot: Fibulin 5/DANCE Antibody (3F8D5) [NB110-60494] - Analysis using fibulin5 mouse mAb against truncated fibulin5 recombinant protein (1) and Hela cell lysate (2).

Product Discontinued

Fibulin 5/DANCE Antibody (3F8D5) Summary

• Immunogen: Purified recombinant fragment of Fibulin 5 expressed in E. Coli.
• Specificity: Fibulin 5 (3F8D5)
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: FBLN5
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Western Blot 1:500 - 1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.03% Sodium Azide
• Purity: Unpurified

Alternate Names for Fibulin 5/DANCE Antibody (3F8D5)

• ARMD3fibulin-5
• DANCE
• DANCEFIBL-5
• Developmental arteries and neural crest EGF-like protein
• EVEC
• FBLN5
• Fibulin 5
• UP50
• UP50FLJ90059
• Urine p50 protein

Background

Fibulin 5(FBLN5), with 448-amino acid protein (about 50kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FBLN5
• Entrez:
  • 423413(Chicken)
  • 10516(Human)