Fibrinogen gamma chain Antibody

Western Blot: Fibrinogen gamma chain Antibody [NBP2-42498] - Staining of Human Platelets lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Fibrinogen gamma chain Antibody Summary

• Immunogen: Peptide with sequence C-KDTVQIHDITGKD corresponding to internal region according to NP_000500.2, NP_068656.2.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_000500.2; NP_068656.2).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FGG
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
  • Western Blot 0.01 - 0.03 ug/ml
• Application Notes: WB: Approx. 50 kDa band observed in human plasma and human platelets lysates (calculated MW of 49.5 kDa band according to NP_000500.2).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Fibrinogen gamma chain Antibody

• fibrinogen gamma chain
• fibrinogen, gamma polypeptide

Background

The protein encoded by the Fibrinogen gamma chain gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Fibrinogen gamma chain Antibody (NBP2-42498)(1)

Publication using NBP2-42498

• Uitte de Willige S, Standeven KF, Philippou H, Ariens RA. The pleiotropic role of the fibrinogen gamma' chain in hemostasis. Blood 2009-11-01 [PMID: 19687509]

Bioinformatics

• Gene Symbol: FGG
• Entrez:
  • 2266(Human)