Human FGFR2 alpha (IIIc), Fc Recombinant Protein

Product Discontinued

Human FGFR2 alpha (IIIc), Fc Recombinant Protein Summary

• Description: A dimeric, glycosylated polypeptide chain consisting of two human FGF-R2a (IIIc) molecules and corresponding to amino acids Arg22 - Glu377 (rHuFGF-R2a (IIIc)) and Pro100 - Lys330 (rHuIgG1) of FGF R2 alpha (P21802).
  
  

  Source: Mouse myeloma cell line, NS0

• Preparation Method: Lyophilized from 0.2 mm filtered concentrated solution in PBS.
• Details of Functionality: The ED50, as determined by the inhibition of rhFGF acidic-dependent NR6R-3T3 cell proliferation, is less than 2 ng/mL.
• Source: Nso cells
• Protein/Peptide Type: Recombinant Protein
• Gene: FGFR2
• Purity: SDS-PAGE
• Endotoxin Note: Less than 1 EU/mg of the rHuFGF-R2a (IIIc) as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • Functional
  • SDS-Page

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: LYOPH
• Purity: SDS-PAGE
• Reconstitution Instructions: Centrifuge prior to opening. Reconstitute with PBS to a final concentration of 0.1 mg/ml. Further dilutions should be made in appropriately buffered solutions.

Notes

This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.

Alternate Names for Human FGFR2 alpha (IIIc), Fc Recombinant Protein

• BBDS;BEK;BFR-1;CD332;CEK3;CFD1;ECT1;Fibroblast growth factor receptor;Fibroblast growth factor receptor 2;JWS;KGFR;K-SAM;Receptor protein-tyrosine kinase;TK14;TK25
• FGF R2a
• FGFR2 alpha

Background

FGF R2 is a transmembrane receptor for fibroblast growth factors that regulate cell growth, differentiation, angiogenesis, wound healing, and tumorigenesis. The FGF R2a (IIIc) isoform of FGF R2 contains all three Ig-like domains in the ECD and an alternative sequence for the C-terminal half of the third Ig-like domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: FGFR2