FCRN/FCGRT Antibody (CL3640) - BSA Free

Western Blot: FCRN/FCGRT Antibody (CL3640) [NBP2-61627] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human cell line THP-1

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody (CL3640) [NBP2-61627] - Staining of human cerebral cortex shows absence of immunoreactivity (negative control).

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody (CL3640) [NBP2-61627] - Staining of human lymph node shows strong positivity in a subset of lymphoid cells.

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody (CL3640) [NBP2-61627] - Staining of human liver shows strong immunoreactivity in Kupffer cells.

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody (CL3640) [NBP2-61627] - Staining of human placenta shows positivity in a subset of lymphoid cells.

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody (CL3640) [NBP2-61627] - Staining of human colon shows immunoreactivity in a subset of lymphoid cells.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: CL3640
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

FCRN/FCGRT Antibody (CL3640) - BSA Free Summary

• Immunogen: This antibody was developed using a recombinant protein derived from P55899, with the exact immunogen sequence remaining proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: FCGRT
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:5000 - 1:10000
  • Immunohistochemistry-Paraffin 1:5000 - 1:10000
  • Western Blot 1 ug/ml
• Application Notes: IHC-Paraffin HIER pH6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Protein A purified

Alternate Names for FCRN/FCGRT Antibody (CL3640) - BSA Free

• alpha-chain
• Fc fragment of IgG, receptor, transporter, alpha
• FCGRT
• FcRn alpha chain
• FCRN
• FCRNimmunoglobulin receptor, intestinal, heavy chain
• IgG Fc fragment receptor transporter alpha chain
• IgG receptor FcRn large subunit p51
• major histocompatibility complex class I-like Fc receptor
• Neonatal Fc receptor
• neonatal Fc-receptor for Ig

Background

The FCGRT gene encodes a 365 amino acid long, 39 kDA IgG receptor FcRn large subunit p51 protein that transfers immunoglobulin G antibodies across the placenta from mother to fetus, as well as functions to protect the antibody from degradation. FCGRT interacts with genes CA6, ELANE, AZGP1, B2M, and ALB. It has been linked to diseases such as: lupus, nephritis, leukemia, arthritis, immunodeficiency, epidermolysis bullosa acquisita, persistent fetal circulation syndrome, and pemphigus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FCGRT