Fascin Antibody (FSCN1/418) [DyLight 680]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications Flow, IHC-P
Clone
FSCN1/418
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Fascin Antibody (FSCN1/418) [DyLight 680] Summary

Immunogen
Full length recombinant human FSCN1 protein
Localization
Cytoplasmic
Marker
Dendritic Cell Marker
Specificity
Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FSCN1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody shomld be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Fascin Antibody (FSCN1/418) [DyLight 680]

  • FAN1
  • FAN1,55 kDa actin-bundling protein
  • fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
  • Fascin
  • FLJ38511
  • FSCN1
  • HSN
  • p55actin bundling protein
  • singed (Drosophila)-like (sea urchin fascin homolog like)
  • singed-like (fascin homolog, sea urchin)
  • Singed-like Protein
  • SNL
  • SNLfascin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FSCN1
Entrez