FAM120A Antibody

Images

 
Western Blot: FAM120A Antibody [NBP1-77367] - SK-N-SH cell lysate with FAM120A antibody at (A) 0.5 and (B) 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: FAM120A Antibody [NBP1-77367] - Immunofluorescence of FAM120A in Rat Brain cells with FAM120A antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: FAM120A Antibody [NBP1-77367] - Rat brain tissue with FAM120A antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

FAM120A Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide from near the center of human FAM120A. The immunogen is located within amino acids 610 - 660 of FAM120A.
Specificity
This antibody will not cross-reacti with FAM120B / PGCC1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FAM120A
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
FAM120A Peptide (NBP1-77367PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FAM120A Antibody

  • C9orf10MGC133257
  • chromosome 9 open reading frame 10
  • constitutive coactivator of PPAR-gamma-like protein 1
  • DNA polymerase-transactivated protein 1
  • DNA polymerase-transactivated protein 5
  • DNAPTP1
  • DNAPTP5
  • family with sequence similarity 120A
  • KIAA0183MGC111527
  • OSSA
  • Oxidative stress-associated Src activator
  • Protein FAM120A

Background

FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells. This antibody will not cross-reacti with FAM120B / PGCC1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol FAM120A
Uniprot