ETS1 associated protein II Antibody (TDP2/1258)

Images

 
Immunohistochemistry-Paraffin: ETS1 associated protein II Antibody (TDP2/1258) [NBP2-50070] - Formalin-paraffin human colon carcinoma stained with TDP2 Mab (TDP2/1258)
Immunohistochemistry-Paraffin: ETS1 associated protein II Antibody (TDP2/1258) [NBP2-50070] - Formalin-paraffin human Lung Carcinoma stained with TDP2 MAb (TDP2/1258)
Immunohistochemistry-Paraffin: ETS1 associated protein II Antibody (TDP2/1258) [NBP2-50070] - Formalin-paraffin human Prostate Carcinoma stained with TDP2 MAb (TDP2/1258)
Immunohistochemistry-Paraffin: ETS1 associated protein II Antibody (TDP2/1258) [NBP2-50070] - Formalin-paraffin human Duodenal carcinoma stained with TDP2 Mab (TDP2/1258)
SDS-Page: ETS1 associated protein II Antibody (TDP2/1258) [NBP2-50070]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, IHC-P, PAGE, ICC/IF
Clone
TDP2/1258
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

ETS1 associated protein II Antibody (TDP2/1258) Summary

Immunogen
Recombinant human TDP2 protein
Localization
Nuclear & Cytoplasmic
Specificity
This MAb recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TDP2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5-1ug/million cells
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 0.5-1ug/ml
  • SDS-Page
  • Immunofluorescence 0.5-1ug/ml
Application Notes
Hu Chromosome Location: 6p22.3-22.1
Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Theoretical MW
41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for ETS1 associated protein II Antibody (TDP2/1258)

  • AD022
  • dJ30M3.3
  • EAP2
  • EAPII
  • EC 3.1.4.-
  • ETS1-associated protein 2
  • ETS1-associated protein II
  • MGC111021,5'-Tyr-DNA phosphodiesterase
  • MGC9099,5'-tyrosyl-DNA phosphodiesterase
  • TRAF and TNF receptor associated protein
  • TTRAPTRAF and TNF receptor-associated protein
  • Tyr-DNA phosphodiesterase 2
  • tyrosyl-DNA phosphodiesterase 2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-50071AF350
Alexa Fluor 405 NBP2-50071AF405
Alexa Fluor 488 NBP2-50071AF488
Alexa Fluor 532 NBP2-50071AF532
Alexa Fluor 594 NBP2-50071AF594
Alexa Fluor 647 NBP2-50071AF647
Alexa Fluor 700 NBP2-50071AF700
Alexa Fluor 750 NBP2-50071AF750
Allophycocyanin NBP2-50071APC
Biotin NBP2-50071B
DyLight 350 NBP2-50071UV
DyLight 405 NBP2-50071V
DyLight 488 NBP2-50071G
DyLight 550 NBP2-50071R
DyLight 594 NBP2-50071DL594
DyLight 650 NBP2-50071C
DyLight 680 NBP2-50071FR
DyLight 755 NBP2-50071IR
FITC NBP2-50071F
HRP NBP2-50071H
Janelia Fluor 549 NBP2-50071JF549
Janelia Fluor 646 NBP2-50071JF646
PE NBP2-50071PE
PerCP NBP2-50071PCP

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Bioinformatics

Gene Symbol TDP2