Independent Antibodies: Western Blot: TDP1 Antibody [NB100-81642] - Detection of Human TDP1 on HeLa whole cell lysate using NB100-81642. TDP1 was also immunoprecipitated by rabbit anti-TDP1 antibody NB100-81643.
Immunohistochemistry-Paraffin: TDP1 Antibody [NB100-81642] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- TDP1 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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