ERAB Antibody

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Western Blot: ERAB Antibody [NB300-887] - Analysis of ERAB / HADH2 in Human Brain lysate (RIPA buffer, 30ug total protein per lane) using this antibody at 0.3ug/ml. Primary incubated for 1 hour. Detected by western blot ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

ERAB Antibody Summary

Immunogen
Peptide with sequence CIRLDGAIRMQP corresponding to C-Terminus according to NP_004484.1, NP_001032900.1.
Specificity
This antibody is expected to recognise both reported isoforms.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
HSD17B10
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.3 - 2 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 25 kDa band observed in human brain lysates (calculated MW of 26.9 kDa band according to NP_004484). A minor band of unknown identity was also consistently observed at appr 38 kDa. This band was successfully blocked by incubation with the immunizing peptide.
Positive Control
ERAB Lysate (NBL1-11722)
Publications
Read Publications using
NB300-887 in the following applications:

  • WB
    1 publication

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Rat, Canine, Bovine. Mouse reactivity determined by Western Blot reported in scientific literature (PMID: 17436268).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERAB Antibody

  • 17-beta-HSD 10
  • 17-beta-hydroxysteroid dehydrogenase 10
  • 17b-HSD10
  • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
  • ABAD
  • amyloid-beta peptide binding alcohol dehydrogenase
  • CAMR
  • DUPXp11.22
  • EC 1.1.1.178
  • EC 1.1.1.35
  • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
  • ERAB3-hydroxyacyl-CoA dehydrogenase type-2
  • HADH2AB-binding alcohol dehydrogenase
  • hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme Adehydrogenase, type II
  • hydroxysteroid (17-beta) dehydrogenase 10
  • mental retardation, X-linked, syndromic 10
  • MHBD
  • Mitochondrial ribonuclease P protein 2,3-hydroxyacyl-CoA dehydrogenase type II
  • Mitochondrial RNase P protein 2
  • MRPP2HCD2
  • MRX17
  • MRX31
  • MRXS10
  • SCHAD
  • SDR5C1
  • short chain dehydrogenase/reductase family 5C, member 1
  • short chain L-3-hydroxyacyl-CoA dehydrogenase type 2
  • short chain type dehydrogenase/reductase XH98G2
  • Short-chain type dehydrogenase/reductase XH98G2
  • Type II HADH
  • XH98G2

Background

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ERAB Antibody (NB300-887)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HSD17B10
Entrez
Uniprot